{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:34:47Z","timestamp":1760204087468},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T00:00:00Z","timestamp":1118102400000},"content-version":"vor","delay-in-days":3567,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of the administration of pantothenic acid (PTA) on valproic acid (VPA)\u2010induced teratogenesis was examined in ICR mice. VPA (300, 400, and 500 mg\/kg, s.c.) or PTA (3 \u00d7 10,3 \u00d7 100, and 3 \u00d7 300 mg\/kg, i.p.) was injected on day 8.5 of gestation (plug day = day 0.5). Exencephaly was induced dose dependently by single injections of VPA. three administrations of PTA alone at any dose levels showed neither embryocidal nor teratogenic effects. In combined treatment experiements, PTA (3 \u00d7 300 mg\/kg) was injected 1 hr before, immediately before, and 1 hr after VPA administration. PTA significantly reduced VPA\u2010induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced. The results suggest that PTA reduces the incidence of neural tube defect induced by VPA in mice. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tera.1420520306","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:11:14Z","timestamp":1118506274000},"page":"143-148","source":"Crossref","is-referenced-by-count":18,"title":["Pantothenic acid decreases valproic acid\u2010induced neural tube defects in mice (I)"],"prefix":"10.1002","volume":"52","author":[{"given":"Masako","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Shirota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(83)90602-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90018-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420380312"},{"key":"e_1_2_1_5_1","first-page":"148","volume-title":"Human Reproduction","author":"Cockroft D. L.","year":"1991"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520292609115636"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(92)90137-7"},{"issue":"98","key":"e_1_2_1_9_1","first-page":"83","article-title":"Folate concentrations in woman on antiepileptic drug (AED) therapy (abstract)","volume":"69","author":"Engelsen B.","year":"1984","journal-title":"Acta neurol Scand."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(93)90075-G"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420430612"},{"key":"e_1_2_1_12_1","first-page":"493","article-title":"Effect of folinic acid on valproate\u2010induced neural tube defects in mice treated in vivo or in vitro (abstract)","volume":"45","author":"Hansen D. K.","year":"1992","journal-title":"Teratology"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6392.577"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770010405"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80750-1"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6275.1509"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90557-9"},{"key":"e_1_2_1_18_1","first-page":"957P","article-title":"Effect of prenatal exposure to anticonvulsant agents on maternal and foetal concentrations in the rat","volume":"74","author":"Marden C. M.","year":"1981","journal-title":"Br. J. Pharmacol."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03430200091032"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03410210053035"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(86)90179-X"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90541-5"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/jn\/56.3.349","article-title":"Multiple congenital abnormalities resulting from transitory deficiency of pteroylglutamic acid during gestation in the rats","volume":"56","author":"Nelson M. M.","year":"1955","journal-title":"J. Nutr."},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/jn\/62.3.395","article-title":"Teratogenic effects of pantothenic acid deficiency in the rat","volume":"62","author":"Nelson M. M.","year":"1957","journal-title":"J. Nutr."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90656-6"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1985.248.1.E1"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1093\/jn\/113.10.2107","article-title":"Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine","volume":"113","author":"Shibata K.","year":"1983","journal-title":"J. Nutr."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.9.965"},{"key":"e_1_2_1_29_1","first-page":"273","article-title":"Can vitamins prevent neural tube defects?","volume":"131","author":"Smithells R.","year":"1984","journal-title":"Can. Med. Assoc. J."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.12.911"},{"key":"e_1_2_1_31_1","first-page":"165","volume-title":"Vitamins and Hormones","author":"Tahiliani A. G.","year":"1991"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199204000-00023"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306033282217"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90367-4"},{"key":"e_1_2_1_35_1","first-page":"550","volume-title":"Advances in Epileptology","author":"Trotz M.","year":"1987"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420410408"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1984.tb04796.x"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(91)90017-A"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420520306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420520306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T01:32:52Z","timestamp":1698370372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420520306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1002\/tera.1420520306"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420520306","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}