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Since the marketing of acitretin only one report on human teratogenicity associated with acitretin has been published. The present male fetus showed severe symmetric anomalies of upper and lower limbs, craniofacial anomalies, ear anomalies, and an atrioventricular septal defect (ASD). Although the craniofacial anomalies resemble the abnormalities described in classical \u201cretinoic acid embryopathy,\u201d limb anomalies were seldomly reported after maternal use of vitamin A congeners. However, in laboratory animals limb defects were frequently observed after retinoid exposure in utero. This case emphasizes again that extreme care and precaution are needed before prescribing a potentially teratogenic drug to a fertile woman. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tera.1420520407","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:11:26Z","timestamp":1118506286000},"page":"215-219","source":"Crossref","is-referenced-by-count":47,"title":["Severe limb defects and craniofacial anomalies in a fetus conceived during acitretin therapy"],"prefix":"10.1002","volume":"52","author":[{"given":"Christine E. M.","family":"De Die\u2010Smulders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam C. J. 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