{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:31:58Z","timestamp":1773235918129,"version":"3.50.1"},"reference-count":37,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1004,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Tissue Eng Regen Med"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1002\/term.1634","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T11:54:27Z","timestamp":1356522867000},"page":"n\/a-n\/a","source":"Crossref","is-referenced-by-count":16,"title":["Auricular cartilage repair using cryogel scaffolds loaded with BMP-7-expressing primary chondrocytes"],"prefix":"10.1155","author":[{"given":"S.","family":"Odabas","sequence":"first","affiliation":[{"name":"Chemical Engineering Department and Bioengineering Division and Centre for Bioengineering (Biyomedtek); Hacettepe University; Beytepe; Ankara; Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Feichtinger","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology\/AUVA Research Centre, Austrian Cluster for Tissue Regeneration; European Institute of Excellence on Tissue Engineering and Regenerative Medicine Research (Expertissues EEIG); Vienna; Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Korkusuz","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine; Hacettepe University; Sihhiye; Ankara; Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Inci","sequence":"additional","affiliation":[{"name":"Chemical Engineering Department and Bioengineering Division and Centre for Bioengineering (Biyomedtek); Hacettepe University; Beytepe; Ankara; Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bilgic","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine; Hacettepe University; Sihhiye; Ankara; Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Yar","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine; Gazi University; Ankara; Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Cavusoglu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery, Faculty of Medicine; Kirikkale University; Kirikkale; Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Menevse","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine; Gazi University; Ankara; Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Vargel","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery, Faculty of Medicine; Kirikkale University; Kirikkale; Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Piskin","sequence":"additional","affiliation":[{"name":"Chemical Engineering Department and Bioengineering Division and Centre for Bioengineering (Biyomedtek); Hacettepe University; Beytepe; Ankara; Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","published-online":{"date-parts":[[2012,12,26]]},"reference":[{"key":"10.1002\/term.1634-BIB0001|term1634-cit-0001","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1208\/s12248-009-9143-y","article-title":"Nonviral gene delivery: principle, limitations, and recent progress","volume":"11","author":"Al-Dosari","year":"2009","journal-title":"AAPS J"},{"key":"10.1002\/term.1634-BIB0002|term1634-cit-0002","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jmbbm.2008.05.001","article-title":"Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair","volume":"2","author":"Al-Munajjed","year":"2009","journal-title":"J Mech Behav Biomed"},{"key":"10.1002\/term.1634-BIB0003|term1634-cit-0003","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/PRS.0b013e3181aa0e79","article-title":"Reconstruction of microtia","volume":"124","author":"Bauer","year":"2009","journal-title":"Plast Reconstr Surg"},{"issue":"suppl 1","key":"10.1002\/term.1634-BIB0004|term1634-cit-0004","first-page":"146","article-title":"Application of bone morphogenetic proteins in the treatment of clinical oral and maxillofacial osseous defects","volume":"83","author":"Boyne","year":"2001","journal-title":"J Bone Joint Surg"},{"key":"10.1002\/term.1634-BIB0005|term1634-cit-0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/term.63","article-title":"Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)","volume":"2","author":"Bessa","year":"2008","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1002\/term.1634-BIB0006|term1634-cit-0006","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1097\/SCS.0b013e31821c9464","article-title":"International trends in the treatment of microtia","volume":"4","author":"Breugem","year":"2011","journal-title":"J Craniofac Surg"},{"key":"10.1002\/term.1634-BIB0009|term1634-cit-0009","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1399-3089.2008.00497.x","article-title":"Experimental application of xenogenous antlerogenic cells in replacement of auricular cartilage in rabbits","volume":"6","author":"Cegielski","year":"2008","journal-title":"Xenotransplantation"},{"key":"10.1002\/term.1634-BIB0010|term1634-cit-0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s002239900230","article-title":"Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4 and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts","volume":"60","author":"Chen","year":"1997","journal-title":"Calcif Tissue Int"},{"key":"10.1002\/term.1634-BIB0011|term1634-cit-0011","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00264-007-0423-9","article-title":"OP-1\/BMP-7 in cartilage repair","volume":"6","author":"Chubinskaya","year":"2007","journal-title":"Inter Orthop"},{"key":"10.1002\/term.1634-BIB0012|term1634-cit-0012","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jbm.a.30660","article-title":"Influence of gel properties on neocartilage formation by auricular chondrocytes photoencapsulated in hyaluronic acid networks","volume":"77","author":"Chung","year":"2006","journal-title":"J Biomed Res A"},{"key":"10.1002\/term.1634-BIB0013|term1634-cit-0013","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2106\/00004623-200300003-00018","article-title":"Repair of articular cartilage defects with osteogenic protein-1 (BMP-7) in dogs","volume":"85","author":"Cook","year":"2003","journal-title":"J Bone Joint Surg"},{"key":"10.1002\/term.1634-BIB0014|term1634-cit-0014","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s004180100305","article-title":"Comparison of long-term transgene expression after non-viral and adenoviral gene transfer into primary articular chondrocytes","volume":"116","author":"Dinser","year":"2001","journal-title":"Histochem Cell Biol"},{"key":"10.1002\/term.1634-BIB0015|term1634-cit-0015","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/jor.1100150309","article-title":"Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner","volume":"15","author":"Erickson","year":"1997","journal-title":"J Orthop Res"},{"key":"10.1002\/term.1634-BIB0017|term1634-cit-0017","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/art.10759","article-title":"Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells","volume":"48","author":"Gelse","year":"2003","journal-title":"Arthrit Rheumat"},{"key":"10.1002\/term.1634-BIB0019|term1634-cit-0019","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00405-007-0455-1","article-title":"An animal study on cartilage healing using auricular cartilage as a model","volume":"3","author":"Haberal Can","year":"2008","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1002\/term.1634-BIB0022|term1634-cit-0022","first-page":"267","article-title":"Differentiation and dedifferentiation of cultured chondrocytes: increase in monomeric size of 'cartilage-specific' proteoglycans by dibutyryl cyclic AMP and complete inhibition of their synthesis by retinoic acid","volume":"2","author":"Hiraki","year":"1985","journal-title":"Biochem Int"},{"key":"10.1002\/term.1634-BIB0023|term1634-cit-0023","doi-asserted-by":"crossref","DOI":"10.1002\/term.1464","article-title":"Gelatin cryogels cross-linked with oxidized dextran and containing freshly formed hydroxyapatite as potential bone tissue engineering scaffolds","author":"Inc\u0131","year":"2012","journal-title":"J Tissue Eng Regen Med"},{"issue":"suppl 1","key":"10.1002\/term.1634-BIB0024|term1634-cit-0024","first-page":"173","article-title":"Macroporous interpenetrating cryogel network of poly(acrylonitrile) and gelatin for biomedical applications","volume":"20","author":"Jain","year":"2008","journal-title":"J Mater Sci Mater Med"},{"key":"10.1002\/term.1634-BIB0025|term1634-cit-0025","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2474-7-62","article-title":"Simultaneous gene transfer of bone morphogenetic protein (BMP)-2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression","volume":"7","author":"Kawai","year":"2006","journal-title":"Musculoskel Disord"},{"key":"10.1002\/term.1634-BIB0026|term1634-cit-0026","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-2002-19828","article-title":"Tissue engineering with chondrocytes","volume":"18","author":"Koch","year":"2002","journal-title":"Facial Plastic Surg"},{"key":"10.1002\/term.1634-BIB0027|term1634-cit-0027","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2106\/00004623-199708000-00003","article-title":"Stimulation of proteoglycan synthesis in explants of porcine articular cartilage by recombinant osteogenic protein-1 (bone morphogenetic protein-7)","volume":"79A","author":"Lietman","year":"1997","journal-title":"J Bone Joint Surg"},{"key":"10.1002\/term.1634-BIB0028|term1634-cit-0028","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00418-011-0822-2","article-title":"In vitro and in vivo neo-cartilage formation by heterotopic chondrocytes seeded on PGA scaffolds","volume":"136","author":"Lohan","year":"2011","journal-title":"Histochem Cell Biol"},{"key":"10.1002\/term.1634-BIB0029|term1634-cit-0029","doi-asserted-by":"crossref","first-page":"9604","DOI":"10.1016\/j.polymer.2005.07.089","article-title":"Synthesis and characterization of new injectable and degradable dextran-based hydrogels","volume":"46","author":"Maia","year":"2005","journal-title":"Polymer"},{"key":"10.1002\/term.1634-BIB0031|term1634-cit-0031","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3325\/cmj.2011.52.245","article-title":"Clinical potential and challenges of using genetically modified cells for articular cartilage repair","volume":"52","author":"Madry","year":"2011","journal-title":"Croat Med J"},{"key":"10.1002\/term.1634-BIB0032|term1634-cit-0032","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ijbiomac.2005.12.017","article-title":"Some physical and microstructural properties of genipin-crosslinked gelatin-maltodextrin hydrogels","volume":"38","author":"Nickerson","year":"2006","journal-title":"Int J Biol Macromol"},{"key":"10.1002\/term.1634-BIB0033|term1634-cit-0033","first-page":"411","article-title":"Considerations on the use of ear chondrocytes as donor chondrocytes for cartilage tissue engineering","volume":"41","author":"Osch","year":"2004","journal-title":"Biorheology"},{"key":"10.1002\/term.1634-BIB0052|term1634-cit-0052","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1016\/j.bjps.2007.07.012","article-title":"Microtia: ear reconstruction using tissue expander and autogenous costal cartilage","volume":"61","author":"Pan","year":"2008","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1002\/term.1634-BIB0035|term1634-cit-0035","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"9","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/term.1634-BIB0036|term1634-cit-0036","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1159\/000147272","article-title":"A semiquantitative system for histologic grading of articular cartilage repair","volume":"143","author":"Pineda","year":"1992","journal-title":"Acta Anat"},{"key":"10.1002\/term.1634-BIB0037|term1634-cit-0037","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nbt0398-247","article-title":"Role of morphogenetic proteins in skeletal tissue engineering and regeneration","volume":"16","author":"Reddi","year":"1998","journal-title":"Nat Biotech"},{"key":"10.1002\/term.1634-BIB0038|term1634-cit-0038","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.fsc.2006.01.006","article-title":"Medpor alternative for microtia repair","volume":"14","author":"Romo","year":"2006","journal-title":"Facial Plast Surg Clin North Am"},{"key":"10.1002\/term.1634-BIB0040|term1634-cit-0040","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.otot.2008.10.004","article-title":"Reconstruction of auricular cartilage using tissue-engineering techniques","volume":"19","author":"Rotter","year":"2008","journal-title":"Op Techn Otolaryngol"},{"key":"10.1002\/term.1634-BIB0041|term1634-cit-0041","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/s-2008-1064542","article-title":"Microtia repair","volume":"11","author":"Quatela","year":"1995","journal-title":"Facial Plast Surg"},{"key":"10.1002\/term.1634-BIB0044|term1634-cit-0044","unstructured":"Sch\u00fcler G 2008 Overexpression of BMP-7 in Monolayer Chondrocytes"},{"key":"10.1002\/term.1634-BIB0047|term1634-cit-0047","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1042\/0264-6021:3600461","article-title":"Regulation of type II collagen gene expression during human chondrocyte dedifferentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility group box (SOX) transcription factors","volume":"360","author":"Stokes","year":"2001","journal-title":"Biochem J"},{"key":"10.1002\/term.1634-BIB0049|term1634-cit-0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbm.a.30655","article-title":"Cartilage tissue engineering using human auricular chondrocytes embedded in different hydrogel materials","volume":"1","author":"Yamaoka","year":"2006","journal-title":"J Biomed Res A"},{"key":"10.1002\/term.1634-BIB0051|term1634-cit-0051","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.biomaterials.2004.06.021","article-title":"Hyaluronic acid modified biodegradable scaffolds for cartilage tissue engineering","volume":"14","author":"Yoo","year":"2005","journal-title":"Biomaterials"}],"container-title":["Journal of Tissue Engineering and Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fterm.1634","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/term.1634\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T13:24:05Z","timestamp":1671542645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/term.1634"}},"subtitle":["Auricular cartilage repair with BMP-7-expressing primary chondrocytes"],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":37,"URL":"https:\/\/doi.org\/10.1002\/term.1634","relation":{},"ISSN":["1932-6254"],"issn-type":[{"value":"1932-6254","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}