{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:31Z","timestamp":1791395491621,"version":"4.3.3"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metabolic products are often more toxic than their pharmacological parent compounds. Therefore, the acute and chronic effects of the main metabolites\u2014salicylic acid (SAL), gentisic acid (GEN), and <jats:italic>o<\/jats:italic>\u2010hydroxyhippuric acid (HDP)\u2014of acetylsalicylic acid (ASA), the active ingredient in Aspirin\u00ae and many other pharmaceuticals, were assessed using standard (<jats:italic>Daphnia magna<\/jats:italic>) and autochthonous (<jats:italic>Daphnia longispina<\/jats:italic>) cladocerans. The sequence of decreasing levels of acute and chronic toxicity of ASA metabolites to daphnids was GEN &gt; SAL &gt; HDP. HDP did not present acute toxicity, but chronic exposures enabled the production of abnormal neonates and, in particular, egg abortion. Thus, reproduction was the end point most susceptible to HDP. On the other hand, SAL and GEN induced changes in the normal patterns of reproduction and growth of both species. In general, <jats:italic>D. longispina<\/jats:italic> was more sensitive than was <jats:italic>D. magna<\/jats:italic>, although the population growth of the autochthonous species was superior under SAL exposures than that of the standard test species. Although the concentrations that were determined to have a toxic effect were above the levels detected in aquatic environmental samples, exposure to low levels of pharmacologically active substances for a duration longer than the test period may induce changes in nontarget organisms. \u00a9 2004 Wiley Periodicals, Inc. Environ Toxicol 19: 527\u2013540, 2004.<\/jats:p>","DOI":"10.1002\/tox.20060","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T09:29:53Z","timestamp":1095154193000},"page":"527-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Life\u2010history traits of standard and autochthonous cladocerans: II. 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