{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:56:35Z","timestamp":1786978595072,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,9]],"date-time":"2006-03-09T00:00:00Z","timestamp":1141862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aquatic organisms are exposed to a variety of natural chemical stressors such as humic substances. The aim of this study was to investigate the mode of action of natural organic matter (NOM, roughly 80% of which is humic substances) on two freshwater amphipods from Lake Baikal,\n                    <jats:italic>Eulimnogammarus verrucosus<\/jats:italic>\n                    (Gerstf.) and\n                    <jats:italic>Eulimnogammarus cyaneus<\/jats:italic>\n                    (Dyb.), in order to assess the potential oxidative stress of NOM impact. Chosen as oxidative stress markers were lipid peroxidation and cell internal hydrogen peroxide level as well as peroxidase, catalase, and glutathione\n                    <jats:italic>S<\/jats:italic>\n                    \u2010transferase activities. Exposure of amphipods to NOM caused a significant increase in lipid peroxidation but a concomitant decrease in hydrogen peroxide concentration, and peroxidase and (to a lesser degree) glutathione\n                    <jats:italic>S<\/jats:italic>\n                    \u2010transferase activities. An interim increase of catalase activity was observed. A possible reason for the decrease in major antioxidant enzyme activity is exhaustion of the reservoir of reduced substrates in the first stage of the antioxidant defense reaction. Despite the inhibition of major antioxidant enzymes, the studied amphipods were able to successfully resist the NOM oxidative impact and, at low NOM concentrations, to combat lipid peroxidation processes. \u00a9 2006 Wiley Periodicals, Inc. Environ Toxicol 21: 104\u2013110, 2006.\n                  <\/jats:p>","DOI":"10.1002\/tox.20161","type":"journal-article","created":{"date-parts":[[2006,3,9]],"date-time":"2006-03-09T12:17:45Z","timestamp":1141906665000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Specific antioxidant reactions to oxidative stress promoted by natural organic matter in two amphipod species from Lake Baikal"],"prefix":"10.1002","volume":"21","author":[{"given":"Maxim A.","family":"Timofeyev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanna M.","family":"Shatilina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksey V.","family":"Kolesnichenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria V.","family":"Kolesnichenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian E. 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