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This study represents an assessment of the interactive effects of the antifouling biocides combined with each other, and with three heavy metals (Cu, Cd, and Zn) in binary mixtures, on the marine algae <jats:italic>Chaetoceros gracilis<\/jats:italic>. Seventy\u2010two hour growth inhibition tests were carried out, and the IC<jats:sub>50<\/jats:sub> values of the chemicals were determined along with growth inhibition (%) for several concentrations. The joint effect of the binary mixtures of all the chemicals was assessed by using two models, concentration addition model and the model of probabilities. The following increasing order of toxicity was obtained: Cd &lt; Zn &lt; Cu &lt; Diuron &lt; Zn pyrithione &lt; Irgarol 1051. The interactive effects of the organic chemicals combined with each other on the growth of <jats:italic>Ch. gracilis<\/jats:italic> were firmly synergistic. Irgarol 1051 combined with Cd performed synergistic effects, and Zn pyrithione with copper and cadmium action was strictly antagonistic, and the results of the two models were in agreement in almost all mixtures. \u00a9 2006 Wiley Periodicals, Inc. 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