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Histological evidences showed that proliferating vacuolar cells extended their growth to the muscle region, and consequently caused the wavy\u2010notochord phenotypes. Interestingly, those malformations can be greatly reversed by exposure with copper, suggesting that copper plays an important role on wavy\u2010notochord phenotypes. In addition, after long\u2010term copper exposure, the surviving larvae derived from wavy\u2010notochord mutants displayed bone malformations, such as twisted axial skeleton and osteophyte. These phenotypic changes and molecular evidences of wavy\u2010notochord mutants are highly similar to those embryos whose lysyl oxidases activities have been inactivated. Taken together, we propose that (i) the putative mutated genes of this wavy\u2010notochord mutant might be highly associated with the lysyl oxidase genes in zebrafish; and (ii) this fish model is an effective tool for monitoring copper pollution of water from natural resources. \u00a9 2009 Wiley Periodicals, Inc. 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