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Therefore, we evaluated the possible teratogenic effects and genotoxic of SnCl<jats:sub>2<\/jats:sub> in zebrafish (<jats:italic>Danio rerio<\/jats:italic>) adults and their embryos. In the embryo\u2013larval study, SnCl<jats:sub>2<\/jats:sub> showed embryo toxicity and developmental delay after exposure to the various concentrations of 10\u2013250 \u03bcM for 120 h. Teratogenic effects including morphological malformations of the embryos and larvae were observed. The embryos exposed to 100 \u03bcM displayed tail deformation at 28 hpf and the larvae exposed to 50 \u03bcM showed reduced body growth, smaller head and eyes, bent trunk, mild pericardial edema, and smaller caudal fin at 96 hpf. The results of the teratological study show that SnCl<jats:sub>2<\/jats:sub> induced a significant decrease in the number of living embryos and larvae. Regarding the chromosome analysis, SnCl<jats:sub>2<\/jats:sub> induced a dose\u2010dependent increase in the micronucleus (MN) frequency in peripheral erythrocytes of adult zebrafish. In blood cells, the 25 \u03bcM dose of SnCl<jats:sub>2<\/jats:sub> caused a nonsignificant increase in the total chromosomal aberrations, but the high doses significantly increased the total number of chromosomal aberrations compared with the control groups. Overall, the results clearly indicate that SnCl<jats:sub>2<\/jats:sub> is teratogenic and genotoxic to zebrafish. \u00a9 2009 Wiley Periodicals, Inc. 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