{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:55:07Z","timestamp":1791644107295,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T00:00:00Z","timestamp":1290988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exposure to sublethal hexavalent chromium (as 2 and 4 mg L<jats:sup>\u22121<\/jats:sup> potassium dichromate for 1 and 2 months) during late preparatory to mid prespawning phase of annual reproductive cycle severely affected the pituitary\u2010ovarian axis of a teleost <jats:italic>Channa punctatus<\/jats:italic>. Gonadosomatic index (GSI), ovarian histopathology, immunocytochemistry of the pituitary gonadotrophs (LH\u03b2\u2010immunoreactive cells), and serum 17\u03b2\u2010estradiol level revealed distinct dose and duration\u2010dependent effects. Gonadosomatic index was declined. Diameter of ovary as well as ovarian follicles was reduced along with a distinct variation in the percentage of follicles. The greater percentage of previtellogenic follicles (stage I) and decline in vitellogenic ones (stage II and stage III) compared to control indicated the arrest of follicular development. The percentage of atretic follicles was also increased indicating toxic impact of metal on ovary. Decreased serum level of ovarian steroid 17\u03b2\u2010estradiol further indicated the same. Chromium interference of the pituitary was demonstrated as atrophy and less immunointensity of LH\u2010immunoreactive gonadotrophs. Thus, the hexavalent chromium impaired the pituitary\u2010ovarian axis affecting at the sites of both pituitary and ovary. \u00a9 2010 Wiley Periodicals, Inc. Environ Toxicol, 2012.<\/jats:p>","DOI":"10.1002\/tox.20654","type":"journal-article","created":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T20:40:43Z","timestamp":1291063243000},"page":"415-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of sublethal hexavalent chromium exposure on the pituitary\u2010ovarian axis of a teleost, <i>Channa punctatus<\/i> (Bloch)"],"prefix":"10.1002","volume":"27","author":[{"given":"Ashish K.","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banalata","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2005.11.004"},{"key":"e_1_2_6_3_1","volume-title":"Standard Methods for the Examination of Water and Wastewater","author":"APHA","year":"1995"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei148"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.06.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02772240600635985"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0043-1354(85)90202-7"},{"key":"e_1_2_6_8_1","unstructured":"Blacksmith Institute: Projects. 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