{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:10:57Z","timestamp":1791576657820,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T00:00:00Z","timestamp":1387324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2015,5,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Acute exposure to hexavalent chromium (10 mg L<jats:sup>\u22121<\/jats:sup>, 20 mg L<jats:sup>\u22121<\/jats:sup>, and 40 mg L<jats:sup>\u22121<\/jats:sup> potassium dichromate for 96 h) dose\u2010dependently affected the pituitary\u2013thyroid axis of teleost, <jats:italic>Channa punctatus<\/jats:italic>. Significant hypertrophy of the thyroid follicle was observed in 20 mg L<jats:sup>\u22121<\/jats:sup> and 40 mg L<jats:sup>\u22121<\/jats:sup> groups; the follicular epithelium was however hypertrophied only in 40 mg L<jats:sup>\u22121<\/jats:sup> group. The colloid depletion in the lumen of thyroid follicle was evident in 20 mg L<jats:sup>\u22121<\/jats:sup> and 40 mg L<jats:sup>\u22121<\/jats:sup> groups. Serum thyroid hormones (thyroxine\/T4 and triiodothyronine\/T3) level increased significantly at both the higher doses. Increased immunointensity and significant hypertrophy of the pituitary thyrotrophs (anti TSH\u03b2\u2010immunoreactive cells) was observed in both 20 mg L<jats:sup>\u22121<\/jats:sup> and 40 mg L<jats:sup>\u22121<\/jats:sup> chromium\u2010exposed fish. The increased thyroid hormones secretion observed in this study might be an adaptive response of the pituitary\u2013thyroid axis under acute chromium\u2010induced stress condition to maintain homeostasis. The long\u2010term Cr(VI) exposures, however, may lead to attenuation\/exhaustion of the pituitary\u2013thyroid axis and pose serious threat to fish health and affect their population. \u00a9 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 621\u2013627, 2015.<\/jats:p>","DOI":"10.1002\/tox.21939","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T05:50:41Z","timestamp":1387345841000},"page":"621-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of acute hexavalent chromium exposure on pituitary\u2013thyroid axis of a freshwater fish, <i>Channa punctatus<\/i> (Bloch)"],"prefix":"10.1002","volume":"30","author":[{"given":"Ashish K.","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Zoology University of Allahabad Allahabad 211002 Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banalata","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Zoology University of Allahabad Allahabad 211002 Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00877638"},{"key":"e_1_2_6_3_1","volume-title":"Standard methods for the examination of water and wastewater","author":"APHA","year":"1995"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/fsim.2000.0281"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02772240600635985"},{"key":"e_1_2_6_6_1","unstructured":"Blacksmith Institute: Projects. 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