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The main route of cadmium exposure to humans is through inhalation. Lungs respond to insult through secretion of cytokines. In this study, the chemoprotective effect of monoisoamyl 2, 3\u2010dimercaptosuccinate (MiADMS) was evaluated on viability and cytokines expression in CdCl<jats:sub>2<\/jats:sub> treated human lung A549 cells by cytokine array. Cells were treated with 0, 50, 75, and 100 \u00b5M CdCl<jats:sub>2<\/jats:sub> alone, 300 \u00b5M MiADMS alone, and co\u2010treated with 300 \u00b5M MiADMS and 75 \u00b5M CdCl<jats:sub>2<\/jats:sub> for 24 h. The viability was measured by crystal violet dye. The level of cytokines in the cells' lysate and cell culture medium was measured using Ray Biotech's Human Cytokine Array 6 in control cells, 75 \u00b5M CdCl<jats:sub>2<\/jats:sub> alone and MiADMS co\u2010treated cells. Array results were validated by ELISA kit. The CdCl<jats:sub>2<\/jats:sub> caused a dose dependent decrease in cell viability, while MiADMS co\u2010treatment resulted in a significant increase in viability of CdCl<jats:sub>2<\/jats:sub> treated cells. Morphology of the cells treated with CdCl<jats:sub>2<\/jats:sub> was destroyed, while MiADMS restored the lost shape in CdCl<jats:sub>2<\/jats:sub> treated cells. In addition, the cells co\u2010treated with MiADMS and CdCl<jats:sub>2<\/jats:sub> showed modulation of cytokines expression in comparison to the CdCl<jats:sub>2<\/jats:sub> alone treated cells. The ELISA results showed the similar pattern of cytokine expression as Human Cytokine Array and validated the array results. These results clearly show the chemoprotective effect of MiADMS and suggest that MiADMS can be used as antidote at moderate dose against CdCl<jats:sub>2<\/jats:sub> toxicity. \u00a9 2014 Wiley Periodicals, Inc. 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