{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:55:16Z","timestamp":1786978516961,"version":"build-2736575974"},"reference-count":84,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T00:00:00Z","timestamp":1391990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2015,7,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The contamination of surface waters by different pollutants is an important problem worldwide. In this study, the histopathological effects of water pollution were investigated on freshwater fish species\n                    <jats:italic>Capoeta capoeta<\/jats:italic>\n                    caught from the Karasu River. Fish were caught at three different sites in the Karasu River, namely, A\u015fkale, Dumlu, and Ser\u00e7eme. The histological changes in gill and liver of fish were detected microscopically and evaluated with quantitative analyses. In addition, heavy metals have also been determined in surface water samples from these sites. Results showed that the A\u015fkale site was polluted by different kinds of heavy metals. In A\u015fkale site, some heavy metals such as Cd, Al, As, Pb, and Mn levels were mostly detected at concentrations above than the accepted values by the Turkish Standards Institute. The presence of gill and liver histological alterations were assessed by the degree of tissue change (DTC). In gill filaments, hypertrophy and hyperplasia of the gill epithelium, lamellar epithelial lifting, lamellae shortening, vasodilatation, lamellar disorganization, blood congestion, fusion, and aneurysm were observed. In the liver, the changes included an increase in the number and size of melanomacrophage aggregates, nonhomogenous parenchyma, proliferation of the hepatopancreas, sinusoidal dilatation, vacuolization, hypertrophy of the hepatocytes, congestion and degeneration of central vein, blood congestion, pyknotic nucleus, focal necrosis, and hepatic granuloma. The histological lesions were comparatively most severe in liver. The DTC means were varied from slight to moderate of gill and moderate to severe of liver tissue in the A\u015fkale site, thus the site is considered to be of low quality. Some pathological alterations were observed in the Ser\u00e7eme site, although their distribution was lower than sites Dumlu and especially A\u015fkale. The least DTC means of the Ser\u00e7eme site demonstrated their good environmental quality. The results suggest that there is a close relationship between amounts of pathological alterations and environmental contamination. \u00a9 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 904\u2013917, 2015.\n                  <\/jats:p>","DOI":"10.1002\/tox.21965","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T01:36:34Z","timestamp":1391996194000},"page":"904-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Histopathological changes in gill and liver of\n                    <i>Capoeta capoeta<\/i>\n                    living in the Karasu River, Erzurum"],"prefix":"10.1002","volume":"30","author":[{"given":"Hatice","family":"Dane","sequence":"first","affiliation":[{"name":"Department of Biology Faculty of Science Ataturk University 25240 Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turgay","family":"\u015ei\u015fman","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Ataturk University 25240 Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2012.04.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0043-1354(02)00392-5"},{"key":"e_1_2_5_4_1","first-page":"106","article-title":"Textile effluents and their contribution towards aquatic pollution in the Kabul River (Pakistan)","volume":"24","author":"Akif M","year":"2002","journal-title":"J Chem Soc Pak"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3844\/ajassp.2009.2024.2029"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(95)90078-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1081\/ESE-100108477"},{"key":"e_1_2_5_8_1","volume-title":"Standard Methods for the Examination of Water and Wastewater","author":"American Public Health Association","year":"1998"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2004.02.032"},{"key":"e_1_2_5_10_1","first-page":"103","article-title":"Heavy metals pollution and their effects on gills and liver of Clarius gariepinus the Nile catfish inhabiting El\u2010Rahawy Drain, Egypt","volume":"10","author":"Authman MMN","year":"2013","journal-title":"Global Veterinaria"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2006.11.003"},{"key":"e_1_2_5_12_1","first-page":"277","article-title":"Yukar\u0131 Sakarya havzas\u0131nda ya\u015fayan sazan bal\u0131klar\u0131n\u0131n (Cyprinus carpio L., 1758) solunga\u00e7, karaci\u011fer ve b\u00f6brek dokular\u0131n\u0131n histopatolojik olarak incelenmesi","volume":"23","author":"Barlas N","year":"1999","journal-title":"Turk J Vet Anim Sci"},{"key":"e_1_2_5_13_1","first-page":"259","article-title":"Toxic effects of cobalt II chloride on tissue histopathology and serum proteins in Capoeta capoeta capoeta (Guldenstaedt 1772)","author":"Bayram Y","year":"2010","journal-title":"Kafkas Univ Vet Fak Derg 16 (Suppl. B)"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2761.1999.00134.x"},{"key":"e_1_2_5_15_1","first-page":"35","article-title":"Pathologic gill lesions in two edible lagoon fish species, Mulloidichtys flavolineatus and Mugil cephalus, from the Bay of Poudre d'Or, Mauritis, Western Indian Ocean","volume":"1","author":"Bhagwant S","year":"2002","journal-title":"J Mar Sci"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01054986"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1679-62252007000300013"},{"key":"e_1_2_5_18_1","first-page":"954","article-title":"Associations between liver lesions in winter flounder (Pleuronectes americanus) and sediment chemical contaminants from north\u2010east United States estuaries","volume":"55","author":"Chang S","year":"1998","journal-title":"J Mar Sci"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2008.12.009"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5620151027"},{"key":"e_1_2_5_21_1","first-page":"62","article-title":"Histopathological changes in liver of Indian Flying Barb, Esomus danricus (Hamilton\u2010Buchanan), exposed to malathion","volume":"2","author":"Das S","year":"2013","journal-title":"Int J Latest Res Sci Technol"},{"key":"e_1_2_5_22_1","first-page":"57","article-title":"Histopathological alterations in gill and liver anatomy of fresh water, air breathing fish Channa punctatus after pesticide Hilban\u00ae (Chlorpyrifos) treatment","volume":"4","author":"Devi Y","year":"2013","journal-title":"Adv Biores"},{"key":"e_1_2_5_23_1","unstructured":"El\u2010SherifMS El\u2010FekyAM.2008. Effect of ammonia on Nile tilapia (O. niloticus) performance and some hematological and histological measures. In Proceedings of the 8th International Symposium on Tilapia in Aquaculture October 12\u201314 2008 Cairo Egypt. pp.513\u2013530."},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00050.2003"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0147-6513(02)00044-1"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-002-1123-5"},{"key":"e_1_2_5_27_1","first-page":"203","volume-title":"Fish Adaptations","author":"Fernandes MN","year":"2003"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1201\/b11000-7"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2007000300004"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1519-69842011000100026"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.1993.tb00571.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0048-9697(03)00069-X"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.3923\/javaa.2010.798.808"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-445X(95)00042-3"},{"key":"e_1_2_5_35_1","first-page":"2071","article-title":"Histopathological changes in gills, liver and kidney of fresh water fish, Tilapia zillii, exposed to aluminum","volume":"3","author":"Hadi AA","year":"2012","journal-title":"Int J Pharm Life Sci"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020085813555"},{"key":"e_1_2_5_37_1","article-title":"Erzurum ovas\u0131 su kalitesi ve kirlili\u011finin tespiti. Atat\u00fcrk \u00dcniversitesi, Fen Bilimleri Enstit\u00fcs\u00fc, Doktora Tezi","author":"Kali N","year":"2008","journal-title":"117 syf"},{"key":"e_1_2_5_38_1","first-page":"61","article-title":"\u0130zmir k\u00f6rfezinde ya\u015fayan kaya bal\u0131klar\u0131nda (Gobius niger) solunga\u00e7 dokusunda olu\u015fabilecek toksik etkinin \u0131\u015f\u0131k mikroskobik incelenmesi","volume":"46","author":"Katalay S","year":"2007","journal-title":"Ege T\u0131p Dergisi"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/09593339309385326"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-007-8078-3"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20145"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1139\/f95-243"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230390174922"},{"key":"e_1_2_5_44_1","first-page":"113","article-title":"Stress in fishes","volume":"30","author":"Lima LC","year":"2006","journal-title":"Rev Bras Repr Anim"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02472006"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2006.01.077"},{"key":"e_1_2_5_47_1","first-page":"423","article-title":"Histopathological changes in the gills of Puntius ticto (Ham) under dimethoate toxicity","volume":"7","author":"Marutirao GR","year":"2012","journal-title":"Bioscan"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1519-69842002000400010"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02986262"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2006.11.013"},{"key":"e_1_2_5_51_1","first-page":"174","article-title":"Toxicity of heavy metals on fish at Jeddah Coast KSA: Metallothionein expression as a biomarker and histopathological study on liver and gills","volume":"2","author":"Montaser M","year":"2010","journal-title":"World J Fish Mar Sci"},{"key":"e_1_2_5_52_1","first-page":"1","article-title":"Fish gills alterations as potential biomarkers of environmental quality in a eutrophized tropical river in South\u2010Eastern Brazil","volume":"41","author":"Nascimento AA","year":"2011","journal-title":"Anat Histol Embryol"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002160050041"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2005.04.008"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20272"},{"key":"e_1_2_5_56_1","first-page":"55","article-title":"Effect of dimethoate on some histoarchitecture of freshwater fish Oreocromis mossambicus (Peters, 1852)","volume":"5","author":"Parikh PH","year":"2010","journal-title":"Bioscan"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-445X(99)00090-9"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1519-69842012000100015"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5620110312"},{"key":"e_1_2_5_60_1","first-page":"339","volume-title":"Sublethal and Chronic Effects of Pollutants on Freshwater Fish","author":"Poleksic V","year":"1994"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2006.05.007"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0101-81751998000200014"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1006\/eesa.2001.2148"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-95022012000300060"},{"key":"e_1_2_5_65_1","first-page":"1121","article-title":"Histopathological alterations of the gills, liver and kidneys in Anabas testudineus (Bloch) fish living in an unused lignite mine, Li District, Lamphun Province, Thailand","volume":"40","author":"Saenphet S","year":"2009","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao044161"},{"key":"e_1_2_5_67_1","first-page":"7","volume-title":"Interdisciplinary Studies on Environmental Chemistry\u2014Biological Responses to Chemical Pollutants","author":"Shiekh R","year":"2008"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2012.05.007"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00128-012-0841-2"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0141-1136(02)00212-X"},{"key":"e_1_2_5_71_1","first-page":"1","article-title":"PCB28 (2,4,4\u2032\u2010Triklorobifenil) ve PCB52 (2,2\u2032,5,5\u2032\u2010Tetraklorobifenil)'ye maruz kalm\u0131\u015f zebra bal\u0131\u011f\u0131 (Danio rerio) larvalar\u0131ndaki karaci\u011fer histopatolojisi","volume":"24","author":"\u015ei\u015fman T","year":"2007","journal-title":"Istanbul Univ J Fish Aquat Sci"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-445X(96)00808-9"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rse.2005.03.013"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0269-7491(02)00270-1"},{"key":"e_1_2_5_75_1","unstructured":"Turkish Standards Institute.2005. Water Intended for Human Consumption. Standard No.: TS 266 2005."},{"key":"e_1_2_5_76_1","unstructured":"Turkish Water Pollution Control Regulation.2004. In Official gazette numbered 25687 and dated 31 December. p.55."},{"key":"e_1_2_5_77_1","first-page":"41","article-title":"Histopathologic biomarker of fish liver as good bioindicator of water pollution in Sitnica River, Kosovo","volume":"13","author":"Valon M","year":"2013","journal-title":"Global J Sci Front Res"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1382-6689(02)00126-6"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.4025\/actascibiolsci.v35i3.18032"},{"key":"e_1_2_5_80_1","first-page":"95","article-title":"Heavy metal induced histopathological alterations in selected organs of the Cyprinus carpio L","volume":"3","author":"Vinodhini R","year":"2009","journal-title":"(Common Carp). Int J Environ Res"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0048-9697(98)00383-0"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-010-1822-8"},{"key":"e_1_2_5_83_1","first-page":"131","article-title":"Toxic effects of cadmium sulphate on tissue histopathology and serum protein expression in European Chub, Leuciscus cephalus (Linnaeus, 1758)","volume":"17","author":"Y\u0131lmaz M","year":"2011","journal-title":"Kafkas Univ Vet Fak Derg"},{"key":"e_1_2_5_84_1","first-page":"231","article-title":"Metals and histopathological alterations in the liver of Schizothorax niger, Heckel from the Dal Lake of Kashmir Valley","volume":"5","author":"Yousuf R","year":"2012","journal-title":"J Environ Sci Nat Resour"},{"key":"e_1_2_5_85_1","first-page":"413","volume-title":"Ecotoxicologia Aqu\u00e1tica\u2010Princ\u00edpios e Aplica\u00e7\u00f5es","author":"Zagatto PA","year":"2006"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftox.21965","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.21965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:49:41Z","timestamp":1696351781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.21965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,10]]},"references-count":84,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,7,8]]}},"alternative-id":["10.1002\/tox.21965"],"URL":"https:\/\/doi.org\/10.1002\/tox.21965","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,10]]},"assertion":[{"value":"2013-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}