{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:27:13Z","timestamp":1793647633943,"version":"4.5.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":451,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"crossref","award":["DMR-99-170"],"award-info":[{"award-number":["DMR-99-170"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Toxicol."],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1002\/tox.22011","type":"journal-article","created":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T00:48:45Z","timestamp":1402102125000},"page":"1416-1422","source":"Crossref","is-referenced-by-count":14,"title":["Different cellular responses of dexmedetomidine at infected site and peripheral blood of emdotoxemic BALB\/c mice"],"prefix":"10.1002","volume":"30","author":[{"given":"Rick Sai-Chuen","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology; China Medical University Hospital; Taichung Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King-Chuen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia; E-da Hospital \/ I-Shou University; Kaohsiung Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu-Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology; China Medical University Hospital; Taichung Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ying","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology; China Medical University Hospital; Taichung Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology; China Medical University Hospital; Taichung Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Lung","family":"Liao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Chinese Medicine, China Medical University; Taichung 404 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Nan","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology; China Medical University Hospital; Taichung Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Gung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology; China Medical University; Taichung Taiwan Republic of China"},{"name":"Department of Biotechnology; Asia University; Taichung Taiwan Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,7]]},"reference":[{"key":"10.1002\/tox.22011-BIB0001|tox22011-cit-0001","first-page":"185","volume-title":"Complement, Immunology: A Short Course","author":"E","year":"2003","edition":"5"},{"key":"10.1002\/tox.22011-BIB0002|tox22011-cit-0002","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00024382-200309000-00003","article-title":"Early alterations in the number of circulating lymphocyte subpopulations and enhanced proinflammatory immune response during opioid-based general anesthesia","volume":"20","author":"Brand","year":"2003","journal-title":"Shock"},{"key":"10.1002\/tox.22011-BIB0003|tox22011-cit-0003","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni1102-991","article-title":"Cancer immunoediting: From immunosurveillance to tumor escape","volume":"3","author":"Dunn","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1002\/tox.22011-BIB0004|tox22011-cit-0004","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.2353\/ajpath.2006.051104","article-title":"Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response","volume":"168","author":"Gonzalez-Rey","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1002\/tox.22011-BIB0005|tox22011-cit-0005","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/ijc.2910350414","article-title":"Spontaneous and induced primary oncogenesis in natural killer (NK)-cell-deficient beige mutant mice","volume":"35","author":"Haliotis","year":"1985","journal-title":"Int J Cancer"},{"key":"10.1002\/tox.22011-BIB0006|tox22011-cit-0006","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2220\/biomedres.29.189","article-title":"The effects of dexmedetomidine on human neutrophil apoptosis","volume":"29","author":"Kishikawa","year":"2008","journal-title":"Biomed Res"},{"key":"10.1002\/tox.22011-BIB0007|tox22011-cit-0007","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00540-008-0626-2","article-title":"Anesthetics, immune cells, and immune responses","volume":"22","author":"Kurosawa","year":"2008","journal-title":"J Anesth"},{"key":"10.1002\/tox.22011-BIB0008|tox22011-cit-0008","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00004311-200341010-00004","article-title":"Effects of volatile and intravenous anesthetic agents on neutrophil function","volume":"41","author":"Leonard","year":"2003","journal-title":"Int Anesthesiol Clin"},{"key":"10.1002\/tox.22011-BIB0009|tox22011-cit-0009","doi-asserted-by":"crossref","unstructured":"Loken MR Green CI Wells DA 2000 61 82","DOI":"10.1093\/oso\/9780199638253.003.0005"},{"key":"10.1002\/tox.22011-BIB0010|tox22011-cit-0010","first-page":"285","article-title":"(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo","volume":"21","author":"Lu","year":"2007","journal-title":"In Vivo"},{"issue":"7-8","key":"10.1002\/tox.22011-BIB0011|tox22011-cit-0011","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0899-9007(03)00059-5","article-title":"Influence of fructooligosaccharides on Peyer's patch lymphocyte numbers in healthy and endotoxemic mice","volume":"19","author":"Manhart","year":"2003","journal-title":"Nutrition"},{"key":"10.1002\/tox.22011-BIB0012|tox22011-cit-0012","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1213\/00000539-199902000-00042","article-title":"The effects of clonidine and dexmedetomidine on human neutrophil functions","volume":"88","author":"Nishina","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1002\/tox.22011-BIB0013|tox22011-cit-0013","doi-asserted-by":"crossref","first-page":"R38","DOI":"10.1186\/cc8916","article-title":"Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial","volume":"14","author":"Pandharipande","year":"2010","journal-title":"Crit Care"},{"key":"10.1002\/tox.22011-BIB0014|tox22011-cit-0014","doi-asserted-by":"crossref","first-page":"e219","DOI":"10.1016\/j.jss.2012.05.047","article-title":"Dexmedetomidine attenuates lipopolysaccharide-induced proinflammatory response in primary microglia","volume":"179","author":"Peng","year":"2013","journal-title":"J Surg Res"},{"key":"10.1002\/tox.22011-BIB0015|tox22011-cit-0015","unstructured":"Schreiber H 1999 1237 1270"},{"key":"10.1002\/tox.22011-BIB0016|tox22011-cit-0016","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1046\/j.1471-4159.1997.68041633.x","article-title":"Neuronal regulation of interleukin 6 secretion in murine spleen: Adrenergic and opioidergic control","volume":"68","author":"Straub","year":"1997","journal-title":"J Neurochem"},{"key":"10.1002\/tox.22011-BIB0017|tox22011-cit-0017","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1097\/01.CCM.0000128579.84228.2A","article-title":"Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats","volume":"32","author":"Taniguchi","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1002\/tox.22011-BIB0018|tox22011-cit-0018","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00540-008-0611-9","article-title":"Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats","volume":"22","author":"Taniguchi","year":"2008","journal-title":"J Anesth"},{"key":"10.1002\/tox.22011-BIB0019|tox22011-cit-0019","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0065-2776(08)60664-1","article-title":"Biology of natural killer cells","volume":"47","author":"Trinchieri","year":"1989","journal-title":"Adv Immunol"},{"key":"10.1002\/tox.22011-BIB0020|tox22011-cit-0020","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.leukres.2009.01.030","article-title":"Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB\/c mice in vivo","volume":"33","author":"MF","year":"2009","journal-title":"Leuk Res"},{"key":"10.1002\/tox.22011-BIB0021|tox22011-cit-0021","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.iy.02.040184.002143","article-title":"Antigen-presenting function of the macrophage","volume":"2","author":"Unanue","year":"1984","journal-title":"Annu Rev Immunol"},{"key":"10.1002\/tox.22011-BIB0022|tox22011-cit-0022","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1615\/JEnvPathToxOncol.v22.i2.70","article-title":"Perioperative immunosuppression in cancer patients","volume":"22","author":"Vallejo","year":"2003","journal-title":"J Environ Pathol Toxicol Oncol"},{"issue":"1A","key":"10.1002\/tox.22011-BIB0023|tox22011-cit-0023","first-page":"219","article-title":"Diallyl disulfide inhibits WEHI-3 leukemia cells in vivo","volume":"26","author":"Yang","year":"2006","journal-title":"Anticancer Res"},{"key":"10.1002\/tox.22011-BIB0024|tox22011-cit-0024","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1213\/ANE.0b013e31820dcabb","article-title":"Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function","volume":"112","author":"Yuki","year":"2011","journal-title":"Anesth Analg"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftox.22011","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/tox.22011\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T08:01:43Z","timestamp":1716796903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.22011"}},"subtitle":["Immunomodulation of Dexmedetomidine in (Endotoxemic Mice)"],"short-title":[],"issued":{"date-parts":[[2014,6,7]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"URL":"https:\/\/doi.org\/10.1002\/tox.22011","archive":["Portico"],"relation":{},"ISSN":["1520-4081"],"issn-type":[{"value":"1520-4081","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6,7]]}}}