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Nickel poisoning can cause inflammatory reactions, respiratory diseases, and allergic contact dermatitis. To clarify the mechanism by which nickel induces mediators of inflammation, we used the human acute monocytic leukemia THP\u20101 cell line as a model. Interleukin (IL)\u20108 promoter activity as well as gene expression were tested by luciferase assay and real\u2010time polymerase chain reaction. The underlying mechanisms of nickel\u2010induced IL\u20108 were investigated. We found that nickel induced IL\u20108 gene expression via the L\u2010type Ca<jats:sup>2+<\/jats:sup> channel, Toll\u2010like receptor\u20104 (TRL\u20104) and nuclear factor NF\u2010\u03baB signal transduction pathways. Nickel activated NF\u2010\u03baB expression through extracellular signal\u2010regulated kinase 1\/2 phosphorylation and then increased IL\u20108 expression. Thus, the L\u2010type Ca<jats:sup>2+<\/jats:sup> channel and TRL\u20104 play important roles in nickel\u2010induced inflammatory gene expressions. \u00a9 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 5\u201312, 2016.<\/jats:p>","DOI":"10.1002\/tox.22016","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T07:42:36Z","timestamp":1405582956000},"page":"5-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Involvement of L\u2010type Ca<sup>2+<\/sup> channel and toll\u2010like receptor\u20104 in nickel\u2010induced interleukin\u20108 gene expression"],"prefix":"10.1002","volume":"31","author":[{"given":"Chia\u2010Hsien","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Health Industry Management School of Health Care Management, Kainan University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Ang","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College of Medicine, Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Department of Clinical Pharmacy 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