{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:50:28Z","timestamp":1779238228913,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":354,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"International Science and Technology Cooperation Project of Guangdong Province, China","award":["2010B050600004"],"award-info":[{"award-number":["2010B050600004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Toxicol."],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1002\/tox.22044","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T06:55:20Z","timestamp":1410504920000},"page":"295-303","source":"Crossref","is-referenced-by-count":45,"title":["Developmental toxicity, oxidative stress, and related gene expression induced by dioxin-like PCB 126 in zebrafish (<i>D<\/i><i>anio rerio<\/i>)"],"prefix":"10.1002","volume":"31","author":[{"given":"Han","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine; Agricultural College, Guangdong Ocean University; Zhanjiang 524088 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Hong","family":"Nie","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Guangdong Ocean University; Zhanjiang 524088 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Ying","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine; Agricultural College, Guangdong Ocean University; Zhanjiang 524088 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine; Agricultural College, Guangdong Ocean University; Zhanjiang 524088 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Hong","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine; Agricultural College, Guangdong Ocean University; Zhanjiang 524088 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine; Agricultural College, Guangdong Ocean University; Zhanjiang 524088 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Gooneratne","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture and Life Sciences, Lincoln University; Lincoln 7647 New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"10.1002\/tox.22044-BIB0001|tox22044-cit-0001","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tox.2009.05.018","article-title":"Aroclor 1254 induced cytotoxicity and mitochondrial dysfunction in isolated rat hepatocytes","volume":"262","author":"Aly","year":"2009","journal-title":"Toxicology"},{"key":"10.1002\/tox.22044-BIB0002|tox22044-cit-0002","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/toxsci\/kfi073","article-title":"Heart malformation is an early response to TCDD in embryonic zebrafish","volume":"84","author":"Antkiewicz","year":"2005","journal-title":"Toxicol Sci"},{"key":"10.1002\/tox.22044-BIB0003|tox22044-cit-0003","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxlet.2004.01.028","article-title":"Dioxins, dioxin-like PCBs and non-dioxin-like PCBs in foodstuffs: Occurrence and dietary intake in The Netherlands","volume":"151","author":"Baars","year":"2004","journal-title":"Toxicol Lett"},{"key":"10.1002\/tox.22044-BIB0004|tox22044-cit-0004","first-page":"47","article-title":"Mechanisms of TCDD-induced abnormalities and embryo lethality in white leghorn chickens","volume":"136","author":"Blankenship","year":"2003","journal-title":"Comp Biochem Phys C"},{"key":"10.1002\/tox.22044-BIB0005|tox22044-cit-0005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tox.2007.06.102","article-title":"The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats","volume":"239","author":"Bunaciu","year":"2007","journal-title":"Toxicology"},{"key":"10.1002\/tox.22044-BIB0006|tox22044-cit-0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2008.04.041","article-title":"Function of reactive oxygen species during animal development: Passive or active?","volume":"320","author":"Covarrubias","year":"2008","journal-title":"Dev Biol"},{"key":"10.1002\/tox.22044-BIB0007|tox22044-cit-0007","first-page":"R1882","article-title":"Oxidative stress response and gene expression with acute copper exposure in zebrafish (Danio rerio)","volume":"293","author":"Craig","year":"2007","journal-title":"Am J Physiol-Regul I"},{"key":"10.1002\/tox.22044-BIB0008|tox22044-cit-0008","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/etc.2406","article-title":"Zebrafish as a model system to study toxicology","volume":"33","author":"Dai","year":"2014","journal-title":"Environ Toxicol Chem"},{"key":"10.1002\/tox.22044-BIB0009|tox22044-cit-0009","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.envint.2006.12.004","article-title":"Levels of PCDD\/PCDFs and PCBs in edible marine species and human intake: A literature review","volume":"33","author":"Domingo","year":"2007","journal-title":"Environ Int"},{"key":"10.1002\/tox.22044-BIB0010|tox22044-cit-0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/toxsci\/69.1.191","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: Local circulation failure in the dorsal midbrain is associated with increased apoptosis","volume":"69","author":"Dong","year":"2002","journal-title":"Toxicol Sci"},{"key":"10.1002\/tox.22044-BIB0011|tox22044-cit-0011","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0048-9697(00)00598-2","article-title":"Effects of oral exposure to polychlorinated biphenyls (PCBs) on the development and metamorphosis of two amphibian species (Xenopus laevis and Rana temporaria)","volume":"262","author":"Gutleb","year":"2000","journal-title":"Sci Total Environ"},{"key":"10.1002\/tox.22044-BIB0012|tox22044-cit-0012","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0300-483X(99)00221-8","article-title":"The relative abilities of TCDD and its congeners to induce oxidative stress in the hepatic and brain tissues of rats after subchronic exposure","volume":"145","author":"Hassoun","year":"2000","journal-title":"Toxicology"},{"key":"10.1002\/tox.22044-BIB0013|tox22044-cit-0013","first-page":"29","article-title":"Oxidative stress in liver and brain of the hatchling chicken (Gallus domesticus) following in ovo injection with TCDD","volume":"136","author":"Hilscherova","year":"2003","journal-title":"Comp Biochem Phys C"},{"key":"10.1002\/tox.22044-BIB0014|tox22044-cit-0014","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/taap.2001.9150","article-title":"Role of oxidative stress and antioxidant defense in 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl-induced toxicity and species-differential sensitivity in chicken and duck embryos","volume":"172","author":"Jin","year":"2001","journal-title":"Toxicol Appl Pharm"},{"key":"10.1002\/tox.22044-BIB0015|tox22044-cit-0015","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.chemosphere.2009.11.044","article-title":"Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio)","volume":"78","author":"Jin","year":"2010","journal-title":"Chemosphere"},{"key":"10.1002\/tox.22044-BIB0016|tox22044-cit-0016","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.chemosphere.2011.02.034","article-title":"Cypermethrin exposure during puberty induces oxidative stress and endocrine disruption in male mice","volume":"84","author":"Jin","year":"2011","journal-title":"Chemosphere"},{"key":"10.1002\/tox.22044-BIB0017|tox22044-cit-0017","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0300-483X(01)00564-9","article-title":"The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver","volume":"171","author":"Kern","year":"2002","journal-title":"Toxicology"},{"key":"10.1002\/tox.22044-BIB0018|tox22044-cit-0018","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.tox.2005.04.014","article-title":"Effect of Aroclor 1254 on Sertoli cellular antioxidant system, androgen binding protein and lactate in adult rat in vitro","volume":"212","author":"Krishnamoorthy","year":"2005","journal-title":"Toxicology"},{"key":"10.1002\/tox.22044-BIB0019|tox22044-cit-0019","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.envint.2009.11.002","article-title":"Acute toxicity of 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB126) in male Sprague-Dawley rats: Effects on hepatic oxidative stress, glutathione and metals status","volume":"36","author":"Lai","year":"2010","journal-title":"Environ Int"},{"key":"10.1002\/tox.22044-BIB0020|tox22044-cit-0020","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.semcdb.2007.10.004","article-title":"The role of corneal crystallins in the cellular defense mechanisms against oxidative stress","volume":"19","author":"Lassen","year":"2008","journal-title":"Semin Cell Dev Biol"},{"key":"10.1002\/tox.22044-BIB0021|tox22044-cit-0021","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00204-001-0308-4","article-title":"Induction of oxidative stress in rat epididymal sperm after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"76","author":"Latchoumycandane","year":"2002a","journal-title":"Arch Toxicol"},{"key":"10.1002\/tox.22044-BIB0022|tox22044-cit-0022","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0300-483X(01)00563-7","article-title":"The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antioxidant system in mitochondrial and microsomal fractions of rat testis","volume":"171","author":"Latchoumycandane","year":"2002b","journal-title":"Toxicology"},{"key":"10.1002\/tox.22044-BIB0023|tox22044-cit-0023","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s00204-003-0439-x","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress in the epididymis and epididymal sperm of adult rats","volume":"77","author":"Latchoumycandane","year":"2003","journal-title":"Arch Toxicol"},{"key":"10.1002\/tox.22044-BIB0024|tox22044-cit-0024","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.aquatox.2008.07.009","article-title":"Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver","volume":"89","author":"Liu","year":"2008","journal-title":"Aquat Toxicol"},{"key":"10.1002\/tox.22044-BIB0025|tox22044-cit-0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1002\/tox.22044-BIB0026|tox22044-cit-0026","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.drudis.2008.03.002","article-title":"Zebrafish: A predictive model for assessing drug-induced toxicity","volume":"13","author":"McGrath","year":"2008","journal-title":"Drug Discov Today"},{"key":"10.1002\/tox.22044-BIB0027|tox22044-cit-0027","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.envint.2006.06.023","article-title":"Assessment of ecological risk from bioaccumulation of PCDD\/Fs and dioxin-like PCBs in a coastal lagoon","volume":"33","author":"Micheletti","year":"2007","journal-title":"Environ Int"},{"key":"10.1002\/tox.22044-BIB0028|tox22044-cit-0028","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.reprotox.2004.11.011","article-title":"The inhibitory effects of polychlorinated biphenyl Aroclor 1254 on Leydig cell LH receptors, steroidogenic enzymes and antioxidant enzymes in adult rats","volume":"20","author":"Murugesan","year":"2005","journal-title":"Reprod Toxicol"},{"key":"10.1002\/tox.22044-BIB0029|tox22044-cit-0029","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.reprotox.2008.04.003","article-title":"Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells","volume":"25","author":"Murugesan","year":"2008","journal-title":"Reprod Toxicol"},{"key":"10.1002\/tox.22044-BIB0030|tox22044-cit-0030","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ecoenv.2008.09.015","article-title":"Protective effects of vitamin E against 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos","volume":"72","author":"Na","year":"2009","journal-title":"Ecotox Environ Safe"},{"key":"10.1002\/tox.22044-BIB0031|tox22044-cit-0031","doi-asserted-by":"crossref","first-page":"S393","DOI":"10.1016\/j.chemosphere.2006.05.134","article-title":"Immunologic effects of perinatal exposure to dioxins, PCBs and organochlorine pesticides in Japanese infants","volume":"67","author":"Nagayama","year":"2007","journal-title":"Chemosphere"},{"key":"10.1002\/tox.22044-BIB0032|tox22044-cit-0032","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.envpol.2006.01.042","article-title":"Interpreting time trends and biomagnification of PCBs in the Baltic region using the equilibrium lipid partitioning approach","volume":"144","author":"Nfon","year":"2006","journal-title":"Environ Pollut"},{"key":"10.1002\/tox.22044-BIB0033|tox22044-cit-0033","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1023\/A:1020600509965","article-title":"The transcriptional activation of the human copper\/zinc superoxide dismutase gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the antioxidant responsive element and xenobiotic responsive element","volume":"24","author":"Park","year":"2002","journal-title":"Mol Cell Biochem"},{"key":"10.1002\/tox.22044-BIB0034|tox22044-cit-0034","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.aquatox.2011.06.014","article-title":"Molecular and biochemical biomarkers in environmental monitoring: A comparison of biotransformation and antioxidant defense systems in multiple tissues","volume":"105","author":"Regoli","year":"2011","journal-title":"Aquat Toxicol"},{"key":"10.1002\/tox.22044-BIB0035|tox22044-cit-0035","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.freeradbiomed.2010.01.005","article-title":"Exposure to polychlorinated biphenyls enhances lipid peroxidation in human normal peritoneal and adhesion fibroblasts: A potential role for myeloperoxidase","volume":"48","author":"Saed","year":"2010","journal-title":"Free Radical Biol Med"},{"key":"10.1002\/tox.22044-BIB0036|tox22044-cit-0036","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.chemosphere.2005.10.054","article-title":"Concentration changes of PCDDs, PCDFs, and dioxin-like PCBs in human breast milk samples as shown by a follow-up survey","volume":"64","author":"Sasamoto","year":"2006","journal-title":"Chemosphere"},{"key":"10.1002\/tox.22044-BIB0037|tox22044-cit-0037","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0892-0362(96)90001-X","article-title":"Review: Developmental neurotoxicity of PCBs in humans: What do we know and where do we go from here?","volume":"18","author":"Schantz","year":"1996","journal-title":"Neurotoxicol Teratol"},{"key":"10.1002\/tox.22044-BIB0038|tox22044-cit-0038","first-page":"273","article-title":"3,3\u2032,4,4\u2032-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: Relationship to cytochrome P450 1A inactivation and reactive oxygen production","volume":"125","author":"Schlezinger","year":"2000","journal-title":"Comp Biochem Phys C"},{"key":"10.1002\/tox.22044-BIB0039|tox22044-cit-0039","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.aquatox.2006.01.012","article-title":"Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners","volume":"77","author":"Schlezinger","year":"2006","journal-title":"Aquat Toxicol"},{"key":"10.1002\/tox.22044-BIB0040|tox22044-cit-0040","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/mol.56.3.588","article-title":"Oxidative inactivation of cytochrome P-4501A (CYP1A) stimulated by 3,3\u2032,4,4\u2032-tetrachlorobiphenyl: Production of reactive oxygen by vertebrate CYP1As","volume":"56","author":"Schlezinger","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1002\/tox.22044-BIB0041|tox22044-cit-0041","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/toxsci\/65.2.192","article-title":"2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: Altered regional blood flow and impaired lower jaw development","volume":"65","author":"Teraoka","year":"2002","journal-title":"Toxicol Sci"},{"key":"10.1002\/tox.22044-BIB0042|tox22044-cit-0042","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0006-2952(01)00668-2","article-title":"Effects of selected polychlorinated biphenyl (PCB) congeners on hepatic glutathione, glutathione-related enzymes, and selenium status: Implications for oxidative stress","volume":"62","author":"Twaroski","year":"2001","journal-title":"Biochem Pharmacol"},{"key":"10.1002\/tox.22044-BIB0043|tox22044-cit-0043","first-page":"267","volume-title":"The zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Danio rerio)","author":"Westerfield","year":"1995","edition":"3"},{"key":"10.1002\/tox.22044-BIB0044|tox22044-cit-0044","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.aquatox.2006.08.006","article-title":"Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in developing red seabream (Pagrus major) embryo: An association of morphological deformities with AHR1, AHR2 and CYP1A expressions","volume":"80","author":"Yamauchi","year":"2006","journal-title":"Aquat Toxicol"},{"key":"10.1002\/tox.22044-BIB0045|tox22044-cit-0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.reprotox.2009.04.013","article-title":"Zebrafish embryos as models for embryotoxic and teratological effects of chemicals","volume":"28","author":"Yang","year":"2009","journal-title":"Reprod Toxicol"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftox.22044","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/tox.22044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T22:48:28Z","timestamp":1625352508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.22044"}},"subtitle":["PCB126 Induced Oxidative Stress in Zebrafish Embryo"],"short-title":[],"issued":{"date-parts":[[2014,9,12]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"URL":"https:\/\/doi.org\/10.1002\/tox.22044","archive":["Portico"],"relation":{},"ISSN":["1520-4081"],"issn-type":[{"value":"1520-4081","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9,12]]}}}