{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:29:00Z","timestamp":1762252140560},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":336,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Environ. Toxicol."],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1002\/tox.22054","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T07:13:54Z","timestamp":1412061234000},"page":"407-414","source":"Crossref","is-referenced-by-count":19,"title":["Subacute toxicity assessment of diflubenzuron, an insect growth regulator, in adult male rats"],"prefix":"10.1002","volume":"31","author":[{"given":"Aline Lima","family":"de Barros","sequence":"first","affiliation":[{"name":"School of Health Sciences; Federal University of Grande Dourados (UFGD); Dourados Mato Grosso do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Finoto","family":"Cavalheiro","sequence":"additional","affiliation":[{"name":"School of Health Sciences; Federal University of Grande Dourados (UFGD); Dourados Mato Grosso do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexsandra Vila Maior","family":"de Souza","sequence":"additional","affiliation":[{"name":"School of Health Sciences; Federal University of Grande Dourados (UFGD); Dourados Mato Grosso do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giseli Karenina","family":"Traesel","sequence":"additional","affiliation":[{"name":"School of Health Sciences; Federal University of Grande Dourados (UFGD); Dourados Mato Grosso do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janete A.","family":"Anselmo-Franci","sequence":"additional","affiliation":[{"name":"Department of Physiology; Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo (USP); Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e2ndida Aparecida Leite","family":"Kassuya","sequence":"additional","affiliation":[{"name":"School of Health Sciences; Federal University of Grande Dourados (UFGD); Dourados Mato Grosso do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arielle","family":"Cristina Arena","sequence":"additional","affiliation":[{"name":"School of Health Sciences; Federal University of Grande Dourados (UFGD); Dourados Mato Grosso do Sul Brazil"},{"name":"Department of Morphology; Institute of Biosciences of Botucatu, S\u00e3o Paulo State University (UNESP); Botucatu S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"key":"10.1002\/tox.22054-BIB0001|tox22054-cit-0001","volume-title":"Therapeutic Basis of Clinical Pharmacy in the Tropics","author":"Aguwa","year":"2004"},{"key":"10.1002\/tox.22054-BIB0002|tox22054-cit-0002","unstructured":"ANVISA (Agencia Nacional de Vigil\u00e2ncia Sanit\u00e1ria) 1985 http:\/\/portal.anvisa.gov.br\/wps\/wcm\/connect\/af1db2804f8d98c8dc3fbc4c6735\/d17_novo.pdf?MOD=AJPERES&useDefaultText=0&useDefault Desc=0"},{"key":"10.1002\/tox.22054-BIB0004|tox22054-cit-0004","unstructured":"ANVISA (Agencia Nacional de Vigil\u00e2ncia Sanit\u00e1ria) 2010"},{"key":"10.1002\/tox.22054-BIB0005|tox22054-cit-0005","first-page":"159","article-title":"Genotoxic evaluation of the organophosphorous pesticide temephos","volume":"1","author":"Aiub","year":"2002","journal-title":"Genet Mol Res"},{"key":"10.1002\/tox.22054-BIB0006|tox22054-cit-0006","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1080\/15287390802392024","article-title":"Fenvalerate, a pyrethroid insecticide, adversely affects sperm production and storage in male rats","volume":"71","author":"Arena","year":"2008","journal-title":"J Toxicol Environ Health A"},{"key":"10.1002\/tox.22054-BIB0007|tox22054-cit-0007","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/toxsci\/kfg093","article-title":"The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97","volume":"74","author":"Ashby","year":"2003","journal-title":"Toxicol Sci"},{"key":"10.1002\/tox.22054-BIB0008|tox22054-cit-0008","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0971-6580.75843","article-title":"Hematological and biochemical changes due to short-term oral administration of imidacloprid","volume":"18","author":"Balani","year":"2011","journal-title":"Toxicol Int"},{"key":"10.1002\/tox.22054-BIB0009|tox22054-cit-0009","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1080\/15287394.2013.830585","article-title":"Genotoxic and mutagenic effects of Diflubenzuron, an insect growth regulator, on mice","volume":"76","author":"Barros","year":"2013","journal-title":"J Toxicol Environ Health A"},{"key":"10.1002\/tox.22054-BIB0010|tox22054-cit-0010","unstructured":"Berczy ZS Cobb LM Street AE Cherry CP 1975"},{"key":"10.1002\/tox.22054-BIB0011|tox22054-cit-0011","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1191\/096032700678815585","article-title":"Chemical hormesis: its historical foundations as a biological hypothesis","volume":"19","author":"Calabrese","year":"2000","journal-title":"Human Exp Toxicol"},{"key":"10.1002\/tox.22054-BIB0012|tox22054-cit-0012","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1590\/S0034-89102001000300003","article-title":"Susceptibilidade larval de duas popula\u00e7\u00f5es de Aedes aegypti a inseticidas qu\u00edmicos","volume":"35","author":"Campos","year":"2001","journal-title":"Rev Sa\u00fade Publ"},{"key":"10.1002\/tox.22054-BIB0013|tox22054-cit-0013","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1081\/CLT-200026979","article-title":"Health effects of diazinon on a family","volume":"42","author":"Dahlgren","year":"2004","journal-title":"J Toxicol Clin Toxicol"},{"key":"10.1002\/tox.22054-BIB0014|tox22054-cit-0014","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.reprotox.2004.04.011","article-title":"Reproductive evaluation of aqueous crude extract of Achillea millefolium L. (Asteraceae) in Wistar rats","volume":"18","author":"Dalsenter","year":"2004","journal-title":"Reprod Toxicol"},{"key":"10.1002\/tox.22054-BIB0015|tox22054-cit-0015","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.etp.2011.03.002","article-title":"Dichlorvos-induced testicular toxicity in male rats and the protective role of vitamins C and E","volume":"64","author":"Diricana","year":"2011","journal-title":"Exp Toxicol Pathol"},{"key":"10.1002\/tox.22054-BIB0016|tox22054-cit-0016","volume-title":"Diflubenzuron","author":"EHC (Environmental Health Criteria 184)","year":"1996"},{"key":"10.1002\/tox.22054-BIB0017|tox22054-cit-0017","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/jmedent\/31.5.639","article-title":"Insecticide susceptibility in mosquitoes (Diptera: Culicidae) from French Polynesia","volume":"31","author":"Failloux","year":"1994","journal-title":"J Med Entomol"},{"key":"10.1002\/tox.22054-BIB0018|tox22054-cit-0018","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.reprotox.2006.09.002","article-title":"Reproductive effects in male rats exposed to diuron","volume":"23","author":"Fernades","year":"2007","journal-title":"Reprod Toxicol"},{"key":"10.1002\/tox.22054-BIB0019|tox22054-cit-0019","volume-title":"Methods in Toxicology: Male Reproductive Toxicology","author":"Filler","year":"1993"},{"key":"10.1002\/tox.22054-BIB0020|tox22054-cit-0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/10408449209145321","article-title":"Environmental concentrations and aquatic toxicity data on diflubenzuron (Dimilin)","volume":"22","author":"Fisher","year":"1992","journal-title":"Crit Rev Toxicol"},{"key":"10.1002\/tox.22054-BIB0021|tox22054-cit-0021","volume-title":"Clinical laboratory parameters for Crl:CD (SD) rats","author":"Giknis","year":"2006"},{"key":"10.1002\/tox.22054-BIB0022|tox22054-cit-0022","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1152\/ajprenal.00324.2007","article-title":"Adverse renal consequences of obesity","volume":"294","author":"Griffin","year":"2008","journal-title":"AJP Renal Physiol"},{"key":"10.1002\/tox.22054-BIB0023|tox22054-cit-0023","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1473-3099(01)00171-2","article-title":"Dengue: an update","volume":"2","author":"Guzm\u00e1n","year":"2002","journal-title":"Lancet Infect Dis"},{"key":"10.1002\/tox.22054-BIB0024|tox22054-cit-0024","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.etap.2011.01.001","article-title":"Effect of propetamphos on the male rats reproductive system","volume":"31","author":"Ismail","year":"2011","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1002\/tox.22054-BIB0025|tox22054-cit-0025","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/carcin\/bgg079","article-title":"Phenobarbital at low dose exerts hormesis in rat hepatocar-cinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression","volume":"24","author":"Kinoshita","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1002\/tox.22054-BIB0026|tox22054-cit-0026","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jep.2010.06.012","article-title":"Acute and subacute toxicity of ethanol extracts from Salvia przewalskii Maxim in rodents","volume":"131","author":"Li","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"10.1002\/tox.22054-BIB0027|tox22054-cit-0027","first-page":"31","article-title":"Modifica\u00e7\u00e3o da suscetibilidade de Aedes (Stegomyia) aegypti ao temephos","volume":"24","author":"Macoris","year":"1995","journal-title":"Rev Patol Trop"},{"key":"10.1002\/tox.22054-BIB0028|tox22054-cit-0028","first-page":"265","article-title":"Acute effects of diflubenzuron on the freshwater fish Prochilodus lineatus","volume":"148","author":"Maduenho","year":"2008","journal-title":"Commun Pharmacol Toxicol"},{"key":"10.1002\/tox.22054-BIB0029|tox22054-cit-0029","volume-title":"Sanidade de Organismos aqu\u00e1ticos","author":"Martins","year":"2004"},{"key":"10.1002\/tox.22054-BIB0030|tox22054-cit-0030","first-page":"69","article-title":"Insecticide susceptibility of Aedes aegypti from Santo Domingo Dominican Republican","volume":"79","author":"Mekuria","year":"1991","journal-title":"J Am Mosq Control Assoc"},{"key":"10.1002\/tox.22054-BIB0031|tox22054-cit-0031","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1289\/ehp.02110427","article-title":"Summary of the National Toxicology Program's report of the endocrine disruptors low dose peer review","volume":"110","author":"Melnick","year":"2002","journal-title":"Environ Health Perspect"},{"key":"10.1002\/tox.22054-BIB0032|tox22054-cit-0032","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/oem.2005.023036","article-title":"Household exposure to pesticides and risk of childhood acute leukaemia","volume":"63","author":"Menegaux","year":"2006","journal-title":"Occup Environ Med"},{"key":"10.1002\/tox.22054-BIB0033|tox22054-cit-0033","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1080\/15287391003751745","article-title":"Effects of gestational and lactational fenvalerate exposure on immune and reproductive systems of male rats","volume":"73","author":"Nassr","year":"2010","journal-title":"J Toxicol Environ Health A"},{"key":"10.1002\/tox.22054-BIB0034|tox22054-cit-0034","volume-title":"Guideline 407: Repeated Dose 28-day Oral Toxicity Study in Rodents","author":"OECD","year":"1995"},{"key":"10.1002\/tox.22054-BIB0035|tox22054-cit-0035","doi-asserted-by":"crossref","DOI":"10.1787\/9789264070981-en","volume-title":"Guideline 422: Combined Repeated Dose Toxicity Study with theReproduction\/Developmental Toxicity Screening Test","author":"OECD","year":"1996"},{"key":"10.1002\/tox.22054-BIB0036|tox22054-cit-0036","doi-asserted-by":"crossref","DOI":"10.1787\/9789264070684-en","volume-title":"Guideline 407: Repeated Dose 28-day Oral Toxicity Study in Rodents","author":"OECD","year":"2008"},{"key":"10.1002\/tox.22054-BIB0037|tox22054-cit-0037","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity","volume":"245","author":"Ozer","year":"2008","journal-title":"Toxicology"},{"key":"10.1002\/tox.22054-BIB0038|tox22054-cit-0038","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0749-0720(15)30205-X","article-title":"Health implications of residues of veterinary drugs and chemicals in animal tissues","volume":"1","author":"Paige","year":"1999","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"10.1002\/tox.22054-BIB0039|tox22054-cit-0039","first-page":"571","article-title":"Relationship between pesticide exposure and low-grade superficial bladder urothelial carcinoma","volume":"123","author":"Pelaez","year":"2004","journal-title":"Med Clin (Barc)"},{"key":"10.1002\/tox.22054-BIB0040|tox22054-cit-0040","doi-asserted-by":"crossref","DOI":"10.7476\/9788575413173","volume-title":"\u00c9 veneno ou \u00e9 rem\u00e9dio?","author":"Peres","year":"2003"},{"key":"10.1002\/tox.22054-BIB0041|tox22054-cit-0041","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ps.2780200207","article-title":"The cuticle, growth regulators and mounting in insects: the essential background to the action of acylurea insecticides","volume":"20","author":"Reynolds","year":"1987","journal-title":"Pest Sci"},{"key":"10.1002\/tox.22054-BIB0042|tox22054-cit-0042","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1530\/jrf.0.0540103","article-title":"Daily sperm production and epididymal sperm reserves of pubertal and adult rats","volume":"54","author":"Robb","year":"1978","journal-title":"J Reprod Fertil"},{"key":"10.1002\/tox.22054-BIB0043|tox22054-cit-0043","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00204-011-0788-9","article-title":"Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression","volume":"86","author":"Romano","year":"2012","journal-title":"Arch Toxicol"},{"key":"10.1002\/tox.22054-BIB0044|tox22054-cit-0044","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/jee\/71.3.427","article-title":"New substituted benzamines with promising activity against mosquitoes","volume":"71","author":"Schaefer","year":"1978","journal-title":"J Econ Entomol"},{"key":"10.1002\/tox.22054-BIB0045|tox22054-cit-0045","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1590\/S0103-84782003000400002","article-title":"Control of Anticarsia gemmatalis H\u00fcbner (Lepidoptera: Noctuidae) larvae with insect growth regulators","volume":"33","author":"Silva","year":"2003","journal-title":"Cienc Rural"},{"key":"10.1002\/tox.22054-BIB0046|tox22054-cit-0046","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00152193-198005000-00007","article-title":"BUN\/creatinine: your keys to kidney function","volume":"10","author":"Stark","year":"1980","journal-title":"Nursing"},{"key":"10.1002\/tox.22054-BIB0047|tox22054-cit-0047","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00232-012-9429-3","article-title":"Protective effect of blackcurrant on liver cell membrane of rats intoxicated with ethanol","volume":"245","author":"Szachowicz-Petelska","year":"2012","journal-title":"J Membr Biol"},{"key":"10.1002\/tox.22054-BIB0048|tox22054-cit-0048","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1590\/S0102-311X2002000300035","article-title":"Aspectos cr\u00edticos do controle do dengue no Brasil","volume":"18","author":"Tauil","year":"2002","journal-title":"Cad Sa\u00fade P\u00fabl"},{"key":"10.1002\/tox.22054-BIB0049|tox22054-cit-0049","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1590\/S0102-311X2005000500002","article-title":"Dengue and dengue hemorrhagic fever epidemics in Brazil: what research is needed based on trends, surveillance, and control experiences?","volume":"21","author":"Teixeira","year":"2005","journal-title":"Cad Sa\u00fade P\u00fabl"},{"key":"10.1002\/tox.22054-BIB0050|tox22054-cit-0050","volume-title":"Reregistration Eligibility Decision-Diflubenzuron","author":"USEPA (United States Environmental Protection Agency)","year":"1997"},{"key":"10.1002\/tox.22054-BIB0051|tox22054-cit-0051","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3844\/ajptsp.2009.169.173","article-title":"Evaluation of the toxic effects of dihydroartemisinin on the vital organs of Wister Albino rats","volume":"4","author":"Utoh-Nedosa","year":"2009","journal-title":"Am J Pharm Toxicol"},{"key":"10.1002\/tox.22054-BIB0052|tox22054-cit-0052","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr Rev"},{"key":"10.1002\/tox.22054-BIB0053|tox22054-cit-0053","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/toxsci\/kfp204","article-title":"Early-life exposure to dimethoate-induced reproductive toxicity: evaluation of effects on pituitary-testicular axis of mice","volume":"112","author":"Verma","year":"2009","journal-title":"Toxicol Sci"},{"key":"10.1002\/tox.22054-BIB0054|tox22054-cit-0054","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.taap.2005.03.033","article-title":"Acute pesticide poisoning and pesticide registration in Central America","volume":"207","author":"Wesseling","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1002\/tox.22054-BIB0055|tox22054-cit-0055","volume-title":"Principles and Methods of Toxicology","author":"Zenick","year":"1994"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftox.22054","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/tox.22054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T22:34:32Z","timestamp":1625351672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.22054"}},"subtitle":["SUBACUTE TOXICITY OF DIFLUBENZURON IN MALE RATS"],"short-title":[],"issued":{"date-parts":[[2014,9,30]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"URL":"https:\/\/doi.org\/10.1002\/tox.22054","archive":["Portico"],"relation":{},"ISSN":["1520-4081"],"issn-type":[{"value":"1520-4081","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9,30]]}}}