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Limited oral bioavailability (BA) and rapid elimination (as conjugates) in rats is reported for sesamol. Considering its significant antioxidant potential and compromised BA, we packaged sesamol into solid lipid nanoparticles (S\u2010SLNs) to enhance its hepatoprotective bioactivity. S\u2010SLNs prepared by microemulsification method were nearly spherical in shape with an average particle size of 120.30 nm and their oral administration at 8 mg\/kg body weight (BW) showed significantly (<jats:italic>p<\/jats:italic> &lt; 0.001) better hepatoprotection than free sesamol (FS) and a well established hepatoprotective antioxidant silymarin [SILY (25 mg\/kg BW); <jats:italic>p<\/jats:italic> &lt; 0.05) in CCl<jats:sub>4<\/jats:sub> induced sub\u2010chronic liver injury in rats. Evaluations were done in terms of histological changes in the liver tissue, liver injury markers (serum alanine aminotransferase, serum aspartate aminotransferase, and serum lactate dehydrogenase); oxidative stress markers (lipid peroxidation, superoxide dismutase, and reduced glutathione) and proinflammatory response marker (tumor necrosis factor\u2010alpha). \u00a9 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 520\u2013532, 2016.<\/jats:p>","DOI":"10.1002\/tox.22064","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T07:44:36Z","timestamp":1416469476000},"page":"520-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Hepatoprotective effects of sesamol loaded solid lipid nanoparticles in carbon tetrachloride induced sub\u2010chronic hepatotoxicity in rats"],"prefix":"10.1002","volume":"31","author":[{"given":"Neha","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Biotechnology Panjab University Chandigarh 160014 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Khullar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Panjab University Chandigarh 160014 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandita","family":"Kakkar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics University Institute of Pharmaceutical Sciences, Panjab University Chandigarh 160014 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indu Pal","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics University Institute of Pharmaceutical Sciences, Panjab University Chandigarh 160014 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"101","article-title":"More than one way to die: methods to determine TNF\u2010induced apoptosis and necrosis","volume":"98","author":"Berghe TV","year":"2004","journal-title":"Methods Mol Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.11.042"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920006779010601"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31818ede6f"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327110394226"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/934239"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.01.006"},{"key":"e_1_2_6_9_1","unstructured":"CPDB.2007. 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