{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:42:10Z","timestamp":1768887730955,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The present study investigated the response of testes, epididymides and sperm in pubertal Wistar rats following exposure to 0, 0.25, 0.5, 0.75, and 1.0 mg kg<jats:sup>\u22121<\/jats:sup> functionalized multi\u2010walled carbon nanotubes (f\u2010MWCNTs) for 5 days. The results showed that administration of (f\u2010MWCNTs) significantly increased the activities of superoxide dismutase, catalase, and glutathione peroxidase in a dose\u2010dependent manner in both testes and sperm compared with control group. Moreover, the significant decrease in the activity of glutathione\u2010<jats:italic>S<\/jats:italic>\u2010transferase and glutathione level was accompanied with significant elevation in the levels of hydrogen peroxide and malondialdehyde in both testes and sperm of (f\u2010MWCNTs)\u2010treated rats. The spermiogram of (f\u2010MWCNTs)\u2010treated rats indicated significant decrease in epididymal sperm number, sperm progressive motility, testicular sperm number and daily sperm production with elevated sperm abnormalities when compared with the control. Exposure to (f\u2010MWCNTs) decreased plasma testosterone level and produced marked morphological changes including decreased geminal epithelium, edema, congestion, reduced spermatogenic cells and focal areas of tubular degeneration in the testes. The lumen of the epididymides contained reduced sperm cells and there was mild to severe hyperplasia epithelial cells lining the duct of the epididymis. Collectively, pubertal exposure of male rats to (f\u2010MWCNTs) elicited oxidative stress response resulting in marked testicular and epididymides dysfunction. \u00a9 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 543\u2013551, 2016.<\/jats:p>","DOI":"10.1002\/tox.22067","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T07:44:29Z","timestamp":1416469469000},"page":"543-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Responses of testis, epididymis, and sperm of pubertal rats exposed to functionalized multiwalled carbon nanotubes"],"prefix":"10.1002","volume":"31","author":[{"given":"Ebenezer O.","family":"Farombi","sequence":"first","affiliation":[{"name":"Drug Metabolism and Toxicology Research Laboratories Department of Biochemistry College of Medicine, University of Ibadan Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac A.","family":"Adedara","sequence":"additional","affiliation":[{"name":"Drug Metabolism and Toxicology Research Laboratories Department of Biochemistry College of Medicine, University of Ibadan Ibadan 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