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The objective of this study was to evaluate the uterine responsiveness to estradiol after perinatal androgenization. Pregnant Wistar rats were exposed to corn oil or testosterone propionate at 0.05, 0.1, or 0.2 mg\/kg from gestational day 12 until postnatal day 21. Female offspring was challenged with estradiol (E<jats:sub>2<\/jats:sub>) after weaning (0.4 mg\/kg) and at adulthood (10 or 100 \u00b5g\/day), when the pituitary response was also evaluated. At adulthood, control and 0.05 mg\/kg groups presented a uterine weight increment when exposed to 100 \u00b5g\/day of E<jats:sub>2<\/jats:sub>, 0.1 mg\/kg group only responded to 10 \u00b5g\/day of E<jats:sub>2<\/jats:sub>, and the 0.2 mg\/kg group showed increased uterine weight at both doses. The pituitary weight was similarly increased after estradiol stimulation in all experimental groups. In conclusion, testosterone propionate exposure induced an abnormal stimulation of uterine tissue growth by estrogen stimulus without affecting pituitary response. More studies are needed to clarify whether these alterations are capable of impairing the reproductive capacity of the female tract. \u00a9 2015 Wiley Periodicals, Inc. 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