{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:55:38Z","timestamp":1787316938342,"version":"build-2736575974"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the protective effect of curcumin on memory loss and on the alteration of acetylcholinesterase and ectonucleotidases activities in rats exposed chronically to cadmium (Cd). Rats received Cd (1 mg\/kg) and curcumin (30, 60, or 90 mg\/kg) by oral gavage 5 days a week for 3 months. The animals were divided into eight groups: vehicle (saline\/oil), saline\/curcumin 30 mg\/kg, saline\/curcumin 60 mg\/kg, saline\/curcumin 90 mg\/kg, Cd\/oil, Cd\/curcumin 30 mg\/kg, Cd\n                    <jats:italic>\/<\/jats:italic>\n                    curcumin 60 mg\/kg, and Cd\n                    <jats:italic>\/<\/jats:italic>\n                    curcumin 90 mg\/kg. Curcumin prevented the decrease in the step\u2010down latency induced by Cd. In cerebral cortex synaptosomes, Cd\u2010exposed rats showed an increase in acetylcholinesterase and NTPDase (ATP and ADP as substrates) activities and a decrease in the 5\u2032\u2010nucleotidase activity. Curcumin was not able to prevent the effect of Cd on acetylcholinesterase activity, but it prevented the effects caused by Cd on NTPDase (ATP and ADP as substrate) and 5\u2032\u2010nucleotidase activities. Increased acetylcholinesterase activity was observed in different brain structures, whole blood and lymphocytes of the Cd\u2010treated group. In addition, Cd increased lipid peroxidation in different brain structures. Higher doses of curcumin were more effective in preventing these effects. These findings show that curcumin prevented the Cd\u2010mediated memory impairment, demonstrating that this compound has a neuroprotective role and is capable of modulating acetylcholinesterase, NTPDase, and 5\u2032\u2010nucleotidase activities. Finally, it highlights the possibility of using curcumin as an adjuvant against toxicological conditions involving Cd exposure. \u00a9 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 70\u201383, 2017.\n                  <\/jats:p>","DOI":"10.1002\/tox.22213","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T03:11:07Z","timestamp":1448248267000},"page":"70-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Curcumin attenuates memory deficits and the impairment of cholinergic and purinergic signaling in rats chronically exposed to cadmium"],"prefix":"10.1002","volume":"32","author":[{"given":"Pauline","family":"da Costa","sequence":"first","affiliation":[{"name":"Departamento De Bioqu\u00edmica E Biologia Molecular Centro De Ci\u00eancias Naturais E Exatas, Universidade Federal De Santa Maria Campus Universit\u00e1rio, Camobi Santa Maria RS 97105\u2010900 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamile F.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Departamento De 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