{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:33:46Z","timestamp":1772217226841,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study assessed the potential hepatoprotective effect of telmisartan (TLM), a selective angiotensin II type 1 (AT<jats:sub>1<\/jats:sub>) receptor blocker, on carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced acute hepatotoxity in rats. Intraperitoneal injection of male Wistar rats with CCl<jats:sub>4<\/jats:sub> 1 mL\u00a0kg<jats:sup>\u22121<\/jats:sup>, 1:1 mixture with corn oil for 3 days increased serum alanine transaminase, aspartate transaminase, and alkaline phosphatase activities as well as total bilirubin, triglycerides and total cholesterol levels. This is in addition to the disrupted histological architecture in the CCl<jats:sub>4<\/jats:sub> group. Rats receiving CCl<jats:sub>4<\/jats:sub> and co\u2010treated with TLM (3 and 10 mg\u00a0kg<jats:sup>\u22121<\/jats:sup>, orally) showed ameliorated serum biochemical and histological changes almost to the control level. Nevertheless, rats treated with TLM (1 mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) didn't show any significant changes compared to CCl<jats:sub>4<\/jats:sub> intoxicated group. In addition, TLM rectified oxidative status disrupted by CCl<jats:sub>4<\/jats:sub> intoxication. Interestingly, TLM protected against CCl<jats:sub>4<\/jats:sub>\u2010induced expressions of nuclear factor\u2010\u03baB, inducible nitric oxide synthase and cyclooxygenase\u2010II, in a dose related manner. Moreover, TLM (3 and 10 mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) significantly modified CCl<jats:sub>4<\/jats:sub>\u2010induced elevation in tumor necrosis factor\u2010\u03b1 and nitric oxide levels. Furthermore, TLM showed a marked decline in CD68+ cells stained areas and reduced activity of myeloperoxidase enzyme compared to CCl<jats:sub>4<\/jats:sub>\u2010intoxicated group. In conclusion, both doses of TLM (3 and 10 mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) showed significant hepato\u2010protective effects. However, TLM at a dose of 10 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> didn't show significant efficacy above 3 mg\u00a0kg<jats:sup>\u22121<\/jats:sup> which is nearly equivalent to the human anti\u2010hypertensive dose of 40 mg. Thus, may be effective in guarding against several hepatic complications due to its antioxidant and anti\u2010inflammatory activities. \u00a9 2016 Wiley Periodicals, Inc. 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