{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:04:22Z","timestamp":1789787062840,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Grant Commission (UGC), Government of India"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Rheumatoid arthritis (RA) is the most common type of chronic inflammatory disease which is triggered by dysfunction in the immune system which in turn affects synovial joints. Current treatment of RA with NSAIDs and DMRDs is limited by their side effect. As a result, the interest in alternative, well tolerated anti\u2010inflammatory remedies has re\u2010emerged. Our aim was to evaluate the antioxidant and anti\u2010inflammatory activities underlying the anti\u2010RA effect of Yohimbine hydrochloride (YCL) in collagen induced arthritis (CIA) in Wistar rats. The YCL was administered at doses of 5 and 10 mg\u00a0kg<jats:sup>\u22121<\/jats:sup>body weight once daily for 28 days. The effects of treatment in the rats were assessed by biochemical parameter (articular elastase, LPO, GSH, catalase, SOD), hematological parameter (ESR, WBC, C\u2010reactive protein (CRP), immunohistochemical expression (COX2, TNF\u2010\u03b1, and NF\u2010\u03baB), and histological changes in joints. YCL showed anti\u2010RA efficacy as it significantly reduced articular elastase, LPO and catalase level and ameliorates histological changes. This is in addition to its antioxidant efficacy as YCL shown a significant increase in GSH and SOD level. Also, YCL showed effective anti\u2010inflammatory activity as it significantly decreased the expression of COX\u20102, TNF\u2010\u03b1, and NF\u2010\u0138B. The therapeutic effect of YCL against RA was also evident from lower arthritis scoring and reduced hematological parameter (ESR, WBC, and C\u2010reactive protein level). The abilities to inhibit proinflammatory cytokines and modulation of antioxidant states that the protective effect of YCL on arthritis rats might be mediated via the modulation of the immune system. \u00a9 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 619\u2013629, 2017.<\/jats:p>","DOI":"10.1002\/tox.22264","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T20:46:55Z","timestamp":1459457215000},"page":"619-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Yohimbine hydrochloride ameliorates collagen type\u2010II\u2010induced arthritis targeting oxidative stress and inflammatory cytokines in Wistar rats"],"prefix":"10.1002","volume":"32","author":[{"family":"Neha","sequence":"first","affiliation":[{"name":"Heavy Metal and Clinical Toxicology Laboratory, Department of Medical Elementology and Toxicology Jamia Hamdard Hamdard Nagar New Delhi 110062 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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