{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:45:46Z","timestamp":1790419546251,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ASI (Italian Space Agency); University of Rome \u201cTor Vergata\u201d (Spatial Biomedicine Center)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Bone metabolism is affected by mechanical, genetic, and environmental factors and plays a major role in osteoporosis. Nevertheless, the influence of environmental pollution on the occurrence of osteoporosis is still unclear and controversial. In this context, heavy metals are the most important pollutants capable to affect bone mass. The aim of this study was to investigate whether heavy metals accumulation in bone tissues could be related to the altered bone metabolism and architecture of osteoporotic patients. To this end, we analyzed 25 bone head biopsies osteoporotic patients and 25 bone head biopsies of osteoarthritic patients. Moreover we enrolled 15 patients underwent hip arthroplasty for high\u2010energy hip fracture or osteonecrosis of the femoral head as a control group. Bone head biopsies were studied by <jats:italic>BioQuant\u2010osteo<\/jats:italic> software, scanning electron microscopy and Energy Dispersive X\u2010ray microanalysis. We found a prevalence of lead, cadmium and chromium accumulation in osteoporotic patients. Noteworthy, high levels of sclerostin, detected by immunohistochemistry, correlate with the accumulation of heavy metal found in the bone of osteoporotic patients, suggesting a molecular link between heavy metal accumulation and bone metabolism impairment. In conclusion, the presence of heavy metals into bone shed new light on the comprehension of the pathogenesis of osteoporosis since these elements could play a non redundant role in the development of osteoporosis at cellular\/molecular and epigenetic level. Nevertheless, <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> studies need to better elucidate the molecular mechanism in which heavy metals can participate to osteoporosis. \u00a9 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1333\u20131342, 2017.<\/jats:p>","DOI":"10.1002\/tox.22327","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T14:41:01Z","timestamp":1469630461000},"page":"1333-1342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Heavy metals accumulation affects bone microarchitecture in osteoporotic patients"],"prefix":"10.1002","volume":"32","author":[{"given":"Manuel","family":"Scimeca","sequence":"first","affiliation":[{"name":"Department of Spatial Biomedicine, Italian Space Agency (ASI) via Del Politecnico Snc Rome 00133"},{"name":"Anatomic Pathology Section, Department of Biomedicine and Prevention University of Rome \u201cTor Vergata,\u201d via Montpellier 1 Rome 00133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Feola","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology \u201cTor Vergata\u201d University of Rome,\" \u201cPoliclinico Tor Vergata\u201d Foundation Viale Oxford 1 Rome 00133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology \u201cTor Vergata\u201d University of Rome,\" \u201cPoliclinico Tor Vergata\u201d Foundation Viale Oxford 1 Rome 00133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology \u201cTor Vergata\u201d University of Rome,\" \u201cPoliclinico Tor Vergata\u201d Foundation Viale Oxford 1 Rome 00133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gasbarra","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology \u201cTor Vergata\u201d University of Rome,\" \u201cPoliclinico Tor Vergata\u201d Foundation Viale Oxford 1 Rome 00133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bonanno","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Section, Department of Biomedicine and Prevention University of Rome \u201cTor Vergata,\u201d via Montpellier 1 Rome 00133 Italy"},{"name":"TMALab S.R.L., Spin\u2010off of University of Tor Vergata, Department of Biomedicine and Prevenction Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Brandi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Translational Medicine University of Florence Florence 50139 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology \u201cTor Vergata\u201d University of Rome,\" \u201cPoliclinico Tor Vergata\u201d Foundation Viale Oxford 1 Rome 00133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/36593"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-011-0689-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(90)90230-R"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181aba749"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00272-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.05.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","unstructured":"CallanAC DevineA QiL NgJC HinwoodAL.2015. 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