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In this study, the cardio\u2010protective effects of folic acid (FA) in early stage AD was elucidated using a triple\u2010transgenic (3xTg) Alzheimer's mouse model. Eleven\u2010month\u2010old C57BL\/6 mice and 3xTg mice were assigned to five groups. During the four\u2010month treatment period, the low\u2010FA treatment group received FA through their diet, and the high\u2010FA treatment groups received 3 mg\/dl folate in drinking water and were also gastric\u2010fed 1.2 mg\/kg folate every day. In the C57B1\/6J mice, treatment with high doses of FA (HFA) did not show any considerable effect compared to the control group or the low\u2010dose dietary FA treatment group. However, Alzheimer's mice treated with HFA showed enhanced cardio\u2010protection. Western blot analysis revealed that FA treatment restored SIRT1 expression, which was suppressed in 3xTg mice, through enhanced AMPK expression. FA significantly enhanced the IGF1 receptor survival mechanism in the hearts of the 3xTg mice and suppressed the expression\u2010intrinsic and extrinsic apoptosis\u2010associated proteins. The results suggest that FA intake may significantly alleviate cellular pathological events in the heart associated with AD.<\/jats:p>","DOI":"10.1002\/tox.22498","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T05:38:42Z","timestamp":1508909922000},"page":"83-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["RETRACTED: The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple\u2010transgenic Alzheimer's disease model mice"],"prefix":"10.1002","volume":"33","author":[{"given":"Kuan\u2010Ho","family":"Lin","sequence":"first","affiliation":[{"name":"College of Medicine China Medical University Taichung Taiwan"},{"name":"Department of Emergency Medicine China Medical University Hospital Taichung 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University Beigang Hospital Yunlin County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rwei\u2010Fen S.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science , Graduate Institute of Nutrition and Food Science, Fu Jen University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Medical Science, China Medical University Taichung Taiwan"},{"name":"Graduate Institute of Chinese Medical Science, China Medical University Taichung Taiwan"},{"name":"Department of Health and Nutrition Biotechnology Asia University Taichung 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