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The goal of this study was to evaluate the toxicological implications of MgO NPs and MPs after 28 day repeated oral administration in Wistar rats with three different doses (250, 500, and 1000 mg\/kg). The MgO particles were characterised systematically in order to get more insights of the toxicological behaviour. MgO NPs induced significant DNA damage and aberrations in chromosomes. Moreover, hepatic enzymes released into the systemic circulation caused significant elevated levels of physiological enzymes in blood. NPs could interfere with proteins and enzymes and alter the redox balance in cell environment. Significant accumulation of Mg in all tissues and clearance via urine and faeces was noted in size dependent kinetics. Oral administration of MgO NPs altered the biochemical and genotoxic parameters in dose dependent and gender independent manner.<\/jats:p>","DOI":"10.1002\/tox.22526","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T07:02:48Z","timestamp":1514444568000},"page":"396-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Genotoxicity, biochemical, and biodistribution studies of magnesium oxide nano and microparticles in albino wistar rats after 28\u2010day repeated oral exposure"],"prefix":"10.1002","volume":"33","author":[{"given":"Bhanuramya","family":"Mangalampalli","sequence":"first","affiliation":[{"name":"Toxicology Unit, Pharmacology and Toxicology Department CSIR \u2010 Indian Institute of Chemical Technology Hyderabad Telangana 500007 India"},{"name":"Academy of Scientific and Innovative Research, CSIR \u2010 Indian Institute of Chemical Technology Hyderabad Telangana 500007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Dumala","sequence":"additional","affiliation":[{"name":"Toxicology Unit, Pharmacology and Toxicology Department CSIR \u2010 Indian Institute of Chemical Technology Hyderabad Telangana 500007 India"},{"name":"Academy of Scientific and Innovative Research, CSIR \u2010 Indian Institute of Chemical Technology Hyderabad Telangana 500007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekhadevi","family":"Perumalla Venkata","sequence":"additional","affiliation":[{"name":"Toxicology Unit, Pharmacology and Toxicology Department CSIR \u2010 Indian Institute of Chemical Technology Hyderabad Telangana 500007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-8273","authenticated-orcid":false,"given":"Paramjit","family":"Grover","sequence":"additional","affiliation":[{"name":"Toxicology Unit, Pharmacology and Toxicology Department CSIR \u2010 Indian Institute of Chemical Technology Hyderabad Telangana 500007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2jm35087d"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2015.10.027"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1166\/mat.2014.1132"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1049\/iet-nbt.2010.0022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-011-9191-9"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"533","article-title":"Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts","volume":"3","author":"Lai JC","year":"2008","journal-title":"Int J Nanomed."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16047551"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.09.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21908"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233712446723"},{"key":"e_1_2_9_12_1","unstructured":"BurlesonW PicardR.Affective agents: Sustaining motivation to learn through failure and a state of stuck. 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