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It has been found to exert apoptosis\u2010inducing effects against carcinoma cells as well as antiallergic and anti\u2010inflammatory effects in vivo. In the current study, a series of formulations composed of various concentrations of hydroxypropyl methylcellulose (HPMC) with the addition of hyaluronan (HA) and xanthan gum (XG) was designed to evaluate the UVB\u2010screening and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010eliminating effects of farnesol in normal fibroblasts. Farnesol at 0.005, 0.0075, and 0.01% exhibited significant capacity for H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> scavenging; at 0.0025%, it showed insignificant effects. Under 120\u2010min UVB exposure, screening with plural gel composed of 0.0025% farnesol, 0.5% HA, and 0.5% XG containing 1.5% or 2% HPMC retained normal fibroblast viability. After 60\u2010min exposure to UVB, screening with plural gel composed of farnesol, HA, XG, and 0.5%, 1.0%, 1.5%, or 2% HPMC decreased the ratio of the G1 phase and increased ratio of the S phase in comparison with the accumulated cell cycle of the normal fibroblasts without screening. The gel with 2% HPMC displayed the strongest cell cycle\u2010reversal ability. In vivo histopathological results showed that the prepared plural gels with 0.5% or 2% HPMC and farnesol, HA, and XG had greater antiphotoaging and reparative effects against UVB\u2010induced changes and damage in the skin. In conclusion, the current in vitro and in vivo results demonstrated that the prepared plural composed of 0.0025% farnesol, 0.5% HA, 0.5% XG, and 2% HPMC possessed the greatest UVB\u2010screening capacity and the strongest restorative effects on UVB\u2010induced sunburned skin.<\/jats:p>","DOI":"10.1002\/tox.22535","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T07:33:08Z","timestamp":1517297588000},"page":"488-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of the UVB\u2010screening capacity and restorative effects exerted by farnesol gel on UVB\u2010caused sunburn"],"prefix":"10.1002","volume":"33","author":[{"given":"Guan Xuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering I\u2010Shou University Kaohsiung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han 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