{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:45:45Z","timestamp":1778575545725,"version":"3.51.4"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare, Taiwan","doi-asserted-by":"publisher","award":["MOHW106\u2010TDU\u2010B\u2010212\u2010113004"],"award-info":[{"award-number":["MOHW106\u2010TDU\u2010B\u2010212\u2010113004"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heart failure is one of the complications related to periodontal disease. In addition to drugs or herbal medicines, stem cell therapy shows potential in the treatment of cardiomyopathy. This study investigates if stem cells exhibit beneficial effects on cardiomyocyte damage induced by porphyromonas gingivalis endotoxin (Pg\u2010LPS). From the experimental results we find that Pg\u2010LPS reduce cardiomyocyte viability via the activation of apoptosis, hypertrophy, fibrosis and MAPK signaling. Pg\u2010LPS damaged cardiomyocytes co\u2010cultured with adipose\u2010derived stem cells (ADSC) increases cardiomyocyte viability through suppressing the pathological markers described above. Further evidence implies that survival marker, IGF1, secreted from ADSC, may play an important role in the Pg\u2010LPS induced protective effect on cardiomyocyte damage.<\/jats:p>","DOI":"10.1002\/tox.22536","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T12:17:49Z","timestamp":1517401069000},"page":"508-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adipose\u2010derived stem cells decrease cardiomyocyte damage induced by porphyromonas gingivalis endotoxin through suppressing hypertrophy, apoptosis, fibrosis, and MAPK markers"],"prefix":"10.1002","volume":"33","author":[{"given":"Tung\u2010Sheng","family":"Chen","sequence":"first","affiliation":[{"name":"School of Life Science National Taiwan Normal University Taipei Taiwan"},{"name":"Graduate Institute of Basic Medical Science, China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Hua","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Sports Sciences University of Taipei Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarnai","family":"Battsengel","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Medical Science, China Medical University Taichung Taiwan"},{"name":"Intermed Hospital, Chinggis Avenue 41, Khan\u2010Uul district, 15th Khoroo Uildver Ulaanbaatar 17040 Mongolia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lung\u2010Fa","family":"Pan","sequence":"additional","affiliation":[{"name":"Division of Cardiology Armed Force Taichung General Hospital Taichung Taiwan"},{"name":"Department of Medical Imaging and Radiological Sciences of Central Taiwan University of Science and Technology Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia Hsuan","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Nursing MeiHo University Pingtung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Yao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nursing MeiHo University Pingtung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Chin","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Hospital and Health Care Administration Chia Nan University of Pharmacy and Science  Tainan County Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Vijaya","family":"Padma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Bharathiar University Coimbatore 641 046 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Kai","family":"Yao","sequence":"additional","affiliation":[{"name":"Washington High School Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueh\u2010Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology Changhua Christian Hospital Changhua Taiwan"},{"name":"Jen\u2010Teh Junior College of Medicine, Nursing and Management Miaoli Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-0411","authenticated-orcid":false,"given":"Chih\u2010Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Medical Science, China Medical University Taichung Taiwan"},{"name":"Graduate Institute of Chinese Medical Science, China Medical University Taichung Taiwan"},{"name":"Faculty of Applied Sciences Ton Duc Thang University, Tan Phong Ward, District 7 Ho Chi Minh City 700000 Vietnam"},{"name":"Department of Health and Nutrition Biotechnology Asia University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.547"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2016.01.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.04.819"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050070"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1443"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.03.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.08.032"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftox.22536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T23:03:11Z","timestamp":1695682991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.22536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/tox.22536"],"URL":"https:\/\/doi.org\/10.1002\/tox.22536","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]},"assertion":[{"value":"2017-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}