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This study presents the effects of 90\u2010day intragastric administration of HxCN to female Wistar rats at doses of 0.03, 0.1, and 0.3 mg\/kg body weight. The study examined selected parameters of the heme synthesis pathway, oxidative stress, hepatic cytochromes level, and basic hematology indicators. A micronucleus test was also performed. The subchronic exposure of rats to HxCN resulted in disruption of heme biosynthesis, hematological disturbances, and hepatotoxicity. The highest dose of HxCN inhibited aminolevulinic acid dehydratase (ALA\u2010D) and uroporphyrinogen decarboxylase (URO\u2010D). Accumulation of higher carboxylated porphyrins in the liver and increased excretion of 5\u2010aminolevulinic acid in the urine was observed after a dose of 0.1 mg\/kg body weight. The most sensitive effect of HxCN in rats was very strong induction of hepatic CYP1A1 activity, which was observed after the lowest dose. The highest dose of HxCN induced significant thrombocytopenia, thymic atrophy and hepatotoxicity, expressed as hepatomegaly and hepatic steatosis.<\/jats:p>","DOI":"10.1002\/tox.22558","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T01:07:05Z","timestamp":1523927225000},"page":"695-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effects of hexachloronaphthalene on selected parameters of heme biosynthesis and systemic toxicity in female wistar rats after 90\u2010day oral exposure"],"prefix":"10.1002","volume":"33","author":[{"given":"Michal","family":"Klimczak","sequence":"first","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy Medical University of Lodz, Muszynskiego 1 Lodz 90\u2010151 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-3227","authenticated-orcid":false,"given":"Adam","family":"Darago","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy Medical University of Lodz, Muszynskiego 1 Lodz 90\u2010151 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Bruchajzer","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy Medical University of Lodz, Muszynskiego 1 Lodz 90\u2010151 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Domeradzka\u2010Gajda","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Carcinogenesis Nofer Institute of Occupational Medicine, Sw. 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