{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:23:58Z","timestamp":1771561438408,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Taiwan Department of Health Clinical Trial and Research Center of Excellence","award":["MOHW106-TDU-B-212-113004"],"award-info":[{"award-number":["MOHW106-TDU-B-212-113004"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Eriobotrya japonica<\/jats:italic> (EJ) is a traditional Chinese plant with high medicinal value. EJ extracts are reported to exhibit antioxidant and anti\u2010inflammatory biological attributes. The current study aims to evaluate the prospective efficacy of <jats:italic>E. japonica<\/jats:italic> leave extract (EJLE) against Angiotensin\u2010II induced cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats (SHRs). For the in vitro studies, Angiotensin\u2010II pretreated H9c2 cells were treated with EJLE and analyzed through Western blotting and rhodamine phalloidin staining for their cardio\u2010protective attributes. In the in vivo studies, 12\u2010week\u2010old SHRs were randomly divided into groups: SHRs supplemented with EJLE, control SHR group supplemented with PBS; in addition, a control group of Wistar\u2013Kyoto rats (WKY) was also employed. All rats were supplemented twice a week for 8\u2009week time interval. Finally, echocardiography, morphological, histology, and Western blot analysis were performed to assess their role against cardiac hypertrophy. Interestingly, we could observe that supplementation of EJLE could rescue Ang\u2010II induced cardiac hypertrophy as evident through Western blot, rhodamine phalloidin staining, and Hematoxylin\u2010Eosin staining. Notably, morphological and echocardiography data provided further supports for their ability to ameliorate cardiac characteristics. Cumulatively, the results clearly suggests that supplementation of EJLE promotes cardio\u2010protective effects through amelioration of cardiac hypertrophy in vitro and in vivo.<\/jats:p>","DOI":"10.1002\/tox.22589","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T05:19:29Z","timestamp":1530767969000},"page":"1113-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["<i>Eriobotrya japonica<\/i> ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats"],"prefix":"10.1002","volume":"33","author":[{"given":"Jui\u2010Ting","family":"Chiang","sequence":"first","affiliation":[{"name":"Graduate Institute of Aging Medicine China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khan Farheen","family":"Badrealam","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Medical 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