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This study was performed to examine the hepatoprotective effect of ginsenoside Rg1 (Rg1) against CCl<jats:sub>4<\/jats:sub>\u2010induced acute liver injury, and further to elucidate the involvement of Nrf2 signaling pathway in vivo and in vitro. Mice were orally administered Rg1 (15, 30, and 60\u2009mg\/kg) or sulforaphane (SFN) once daily for 1 week prior to 750\u2009\u03bcL\/kg CCl<jats:sub>4<\/jats:sub> injection. The results showed that Rg1 markedly altered relative liver weights, promoted liver repair, increased the serum level of TP and decreased the serum levels of ALT, AST and ALP. Hepatic oxidative stress was inhibited by Rg1, as evidenced by the decrease in MDA, and increases in GSH, SOD, and CAT in the liver. Further research demonstrated that Rg1 suppressed liver inflammation response through repressing the expression levels of inflammation\u2010related genes including TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, COX\u20102, and iNOS. In addition, Rg1 enhanced antioxidative stress and liver detoxification abilities by up\u2010regulating Nrf2 and its target\u2010genes such as GCLC, GCLM, HO\u20101, NQO1, Besp, Mrp2, Mrp3, Mrp4, and down\u2010regulating Cyp2e1. However, the changes in Nrf2 target\u2010genes, as well as ameliorative liver histology induced by Rg1 were abrogated by Nrf2 antagonist all\u2010transretinoic acid in vivo and Nrf2 siRNA in vitro. Overall, the findings indicated that Rg1 might be an effective approach for the prevention against acute liver injury by activating Nrf2 signaling pathway.<\/jats:p>","DOI":"10.1002\/tox.22616","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T10:37:54Z","timestamp":1530527874000},"page":"1050-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Hepatoprotective effect of ginsenoside Rg1 from <i>Panax ginseng<\/i> on carbon tetrachloride\u2010induced acute liver injury by activating Nrf2 signaling pathway in mice"],"prefix":"10.1002","volume":"33","author":[{"given":"Chenqing","family":"Ning","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology College of Pharmacy, Dalian Medical University  Dalian 116044 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