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This study was carried out to investigate the protective efficacy of<jats:italic>Juglans regia<\/jats:italic>vegetable oil (JRVO) against the hepatotoxicity induced by lead. To achieve this aim, adults male rats were treated for 10 days with Pb (0.344\u2009g\/kg bw) associated or not with JRVO (0.9 g\/kg bw). The rats intoxicated by lead exhibited oxidative stress determined by TBARS, protein carbonyls, liver tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), caspase\u20103, and antioxidant status: SOD, CAT, GPx, and GSH. Administration of lead increased the levels of plasma hepatic markers (AST, ALT, LDH) and bilirubin, the lipid profiles (total cholesterol, triglycerides, VLDL\u2010Ch, LDL\u2010Ch levels, TBARS, NOx, and PCO), the plasmatic lipase activity and the inflammatory markers, while the plasmatic ALP decreased. Coadministration of JRVO restored all the hepatic markers, the lipid profiles and the antioxidants to near\u2010normal values and lowered the plasmatic lipase activity as well as the elevated thiobarbituric acid reactive substances. Hepatic histological studies confirmed the beneficial role of JRVO through the amelioration of all biochemical parameters. Our results suggest that<jats:italic>Juglans regia<\/jats:italic>vegetable oil contains promising substances to counteract the lead intoxication and may be efficient in the prevention of hepatotoxicity complications.<\/jats:p>","DOI":"10.1002\/tox.22634","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T05:20:10Z","timestamp":1537852810000},"page":"1261-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Potential immunomodulatory and antioxidant effects of walnut<scp><i>Juglans regia<\/i><\/scp>vegetable oil against lead\u2010mediated hepatic damage and their interaction with lipase activity in rats"],"prefix":"10.1002","volume":"33","author":[{"given":"Ahlem","family":"Soussi","sequence":"first","affiliation":[{"name":"Laboratory of Animal Eco\u2010physiology, Faculty of Sciences Sfax University Sfax Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-3308","authenticated-orcid":false,"given":"Manel","family":"Gargouri","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Eco\u2010physiology, Faculty of Sciences Sfax University Sfax Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelfattah","family":"El Feki","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Eco\u2010physiology, Faculty of Sciences Sfax University Sfax Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74936-0_45"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"229","article-title":"Protective effect of extra metallothionins from rabbit liver induced by zinc on toxicity of lead in rat primary hepatocyte culture","volume":"31","author":"Hao S","year":"2002","journal-title":"Wei Sheng Yan Jiu"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2003.09.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.12.016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.06.019"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-013-0573-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.8542"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2012.749920"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000124477.91474.FF"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.12.2777"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.5.1062S"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331970505600509"},{"key":"e_1_2_9_14_1","unstructured":"BissonM DiderichR HulotC et al. 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