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These toxic effects were associated with not only the inhibition of prostaglandin synthesis but also drug\u2010elevated oxidative stress. To ameliorate these toxicities, natural antioxidants can be used as an alternative and\/or combination therapies. Therefore, the current study was conducted to assess the renoprotective effects of oleuropein against indomethacin\u2010induced renal damages. Male Sprague\u2010Dawley rats were pretreated with oleuropein (75, 150, and 300\u2009mg\/kg), and then treated with indomethacin (25\u2009mg\/kg). To evaluate kidney function, serum blood urea nitrogen, uric acid, and creatinine were measured. In addition, prostaglandin E<jats:sub>2<\/jats:sub>, tumor necrosis factor\u2010alpha, endothelial nitric oxide synthase, caspase\u20103, oxidant\/antioxidant status, and 8\u2010Oxo\u20102\u2032\u2010deoxyguanosine levels were determined for the antioxidative and anti\u2010inflammatory effects of oleuropein. Tissue sections were also histopathologically assessed. The biochemical and histopathological analysis proved the toxic effects of indomethacin on kidney. However, the pretreatment with oleuropein (300\u2009mg\/kg) protects kidney from indomethacin\u2010induced damages. Our study proved that prior administration of oleuropein has renoprotective activity against indomethacin\u2010associated toxicities.<\/jats:p>","DOI":"10.1002\/tox.22658","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T06:40:31Z","timestamp":1538030431000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The efficacy of oleuropein against non\u2010steroidal anti\u2010inflammatory drug induced toxicity in rat kidney"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6208-165X","authenticated-orcid":false,"given":"Kubra","family":"Koc","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science| Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Cerig","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Science 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