{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:38:08Z","timestamp":1791823088485,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T00:00:00Z","timestamp":1538784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/25821\u20102"],"award-info":[{"award-number":["2015\/25821\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For the first time, juvenile toxicity of inorganic arsenic (As) was investigated in male rats, focusing on reproductive effects. As is a metalloid naturally occurring in the environment, being the inorganic forms the most toxics. Contaminated drinking water and agricultural products are the main prospectors of intoxication for general population. In the present study, Wistar male rats (21\u2009days old) were distributed into three groups (<jats:italic>n<\/jats:italic>\u2009=\u200910\/group): control (received vehicle\u2010filtered drinking water), As1 (received AsNaO<jats:sub>2<\/jats:sub> at 0.01\u2009mg\u2009L<jats:sup>\u22121<\/jats:sup>) and As2 (received AsNaO<jats:sub>2<\/jats:sub> at 10 mg\u2009L<jats:sup>\u22121<\/jats:sup>). The animals were euthanized on PND 53. Testicular damages increased in As1 and As2 compared to control (ie, presence of vacuolization, acidophilic cells, and epithelium degeneration). Testicular interstitium of As1 and As2 presented fluid's increase and intense inflammatory infiltration. In the epididymis there was reduction of sperm amount in the lumen, besides epithelium areas presenting cribriform aspect in As1 and As2, exfoliation of cells in the light (in As1) and vacuoles (in As2). In epididymis interstitium, inflammatory infiltrates were observed in initial segment of As1 and As2. AsNaO<jats:sub>2<\/jats:sub> changed immunolabeling pattern for androgen receptor in epididymis of As2, although serum testosterone levels was statistically comparable to control. Mass spectrometry revealed higher As concentrations in testis and epididymis of As2 compared to As1 and Control. These results indicate compromise of spermatogenesis and epididymal histophysiology in AsNaO<jats:sub>2<\/jats:sub>\u2010treated animals, possibly impairing sperm quality and fertility in long\u2010term, even at low levels of exposure. Investigations about the reversibility of reproductive damages are necessary to better understand the mechanisms of As reproductive toxicity.<\/jats:p>","DOI":"10.1002\/tox.22660","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T13:15:10Z","timestamp":1538831710000},"page":"83-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Prepubertal exposure to low doses of sodium arsenite impairs spermatogenesis and epididymal histophysiology in rats"],"prefix":"10.1002","volume":"34","author":[{"given":"Paloma","family":"da Cunha de Medeiros","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Toxicologia Experimental\u2010LATOEX, Departamento de Ci\u00eancias do Mar Universidade Federal de S\u00e3o Paulo (UNIFESP), Campus Baixada Santista  Santos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Rodrigues","family":"Samelo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Toxicologia Experimental\u2010LATOEX, Departamento de Ci\u00eancias do Mar Universidade Federal de S\u00e3o Paulo (UNIFESP), Campus Baixada Santista  Santos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Priscila Gomes","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Toxicologia Experimental\u2010LATOEX, Departamento de Ci\u00eancias do Mar Universidade Federal de S\u00e3o Paulo (UNIFESP), Campus Baixada Santista  Santos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"da Silva Araujo Santiago","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Toxicologia Experimental\u2010LATOEX, Departamento de Ci\u00eancias do Mar Universidade Federal de S\u00e3o Paulo (UNIFESP), Campus Baixada Santista  Santos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Andrei","family":"Duarte","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Santa Maria  Santa Maria Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cdtalo Braga","family":"de Castro","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias do Mar Universidade Federal de S\u00e3o Paulo (UNIFESP), Campus Baixada Santista  Santos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6797-2117","authenticated-orcid":false,"given":"Juliana Elaine","family":"Perobelli","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Toxicologia Experimental\u2010LATOEX, Departamento de Ci\u00eancias do Mar Universidade Federal de S\u00e3o Paulo (UNIFESP), Campus Baixada Santista  Santos S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-8137.2002.00363.x"},{"key":"e_1_2_6_3_1","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR). 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