{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:54:00Z","timestamp":1772711640139,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST106\u20102314\u2010B\u2010039\u2010017\u2010MY3"],"award-info":[{"award-number":["MOST106\u20102314\u2010B\u2010039\u2010017\u2010MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR\u2010107\u2010108"],"award-info":[{"award-number":["DMR\u2010107\u2010108"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>LncRNA transcripts have been emerged as gene regulators through transcriptional and posttranscriptional regulation. Monosodium urate monohydrate (MSU) elicits inflammatory response and a critical regulator of bone erosion in gout. The aim of this study is to clarify the pro\u2010osteogenic role of LncRNA in MSU\u2010induced osteoclast differentiation. We performed microarray analysis to identify stage specific expressions of LncRNA and mRNA during osteoclast differentiation in RAW264.7 cells. Among the 314 pairs of LncRNA\u2010mRNA coexpressed patterns in the osteoclast lineage, 22 pairs revealed to have inflammatory function. Importantly, LncRNA\u2010Jak3 and Jak3 co\u2010expression patterns were significantly upregulated in the osteoclasts. In specific, Jak3 contributes to MSU\u2010induced osteoclasts differentiation by positively regulating expression of the osteoclast factor, nuclear factor of activated T\u2010cells 1 (Nfatc1). Mechanistically, LncRNA\u2010Jak3\u2010mediated Nfatc1 activation upregulated cathepsin K (Ctsk) expressions. LncRNA\u2010Jak3 knockdown abolished formation of MSU\u2010induced mature osteoclasts. In addition, we found that gout patients showed increased levels of LncRNA\u2010Jak3 in the mononuclear cells. Our data demonstrate that the critical functional role of LncRNA\u2010Jak3 in osteoclast differentiation via Jak3\/Nfatc1\/Ctsk axis. Finally, characterization of these regulatory networks is likely to reveal novel drug targets and opportunities for therapeutic intervention in bone erosion.<\/jats:p>","DOI":"10.1002\/tox.22672","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T13:52:48Z","timestamp":1541166768000},"page":"179-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["LncRNA\u2010Jak3:Jak3 coexpressed pattern regulates monosodium urate crystal\u2010induced osteoclast differentiation through Nfatc1\/Ctsk expression"],"prefix":"10.1002","volume":"34","author":[{"given":"Chi\u2010Pin","family":"Lee","sequence":"first","affiliation":[{"name":"Environment\u2010Omics\u2010Disease Research Center China Medical University Hospital, China Medical University  Taichung 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