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The main results showed that the major components of <jats:italic>p<\/jats:italic>EO<jats:italic>Ca<\/jats:italic> are Limonene and Linalool. Additionally, DPPH scavenging ability and \u03b2\u2010carotene bleaching inhibition tests confirmed the antioxidant capacity of <jats:italic>p<\/jats:italic>EO<jats:italic>Ca<\/jats:italic>. Our oil reduced the production of NO by LPS\u2010stimulated RAW264,7 macrophages in a concentration\u2010dependent. This inhibition occurred at a transcriptional level. <jats:italic>p<\/jats:italic>EO<jats:italic>Ca<\/jats:italic> in CCl<jats:sub>4<\/jats:sub> treated rats alleviated hepatotoxicity as monitored by the improvement of hepatic oxidative stress biomarkers levels plasma biochemical parameters, and DNA molecule aspect. Furthermore, the mRNA gene expression of Cu\u2010Zn SOD, CAT, and GPx increased under CCl<jats:sub>4<\/jats:sub>+ <jats:italic>p<\/jats:italic>EO<jats:italic>Ca<\/jats:italic> exposure to reach the same value to the control. Similarly, antioxidant activities of these three enzymes changed in accordance with the mRNA levels. These results were confirmed by the histological results. It seems obvious that the treatment with <jats:italic>p<\/jats:italic>EO<jats:italic>Ca<\/jats:italic> prevented liver damage induced by CCl<jats:sub>4<\/jats:sub>, thus preventing the harmful effects of free radicals.<\/jats:p>","DOI":"10.1002\/tox.22693","type":"journal-article","created":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T09:29:45Z","timestamp":1545470985000},"page":"388-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Potential anti\u2010inflammatory and antioxidant effects of <scp><i>Citrus aurantium<\/i><\/scp> essential oil against carbon tetrachloride\u2010mediated hepatotoxicity: A biochemical, molecular and histopathological changes in adult rats"],"prefix":"10.1002","volume":"34","author":[{"given":"Anis","family":"Ben Hsouna","sequence":"first","affiliation":[{"name":"Department of Life Sciences Faculty of Sciences of Gafsa  Zarroug Gafsa Tunisia"},{"name":"Laboratory of Biotechnology and Plant Improvement Center of Biotechnology of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-3308","authenticated-orcid":false,"given":"Manel","family":"Gargouri","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Ecophysiology, Faculty of Sciences University of Sfax, BP  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wissal","family":"Dhifi","sequence":"additional","affiliation":[{"name":"University of Manouba, ISBST, LR17\u2010ES03 Physiopathology Food and Biomolecules, Biotechpole Sidi Thabet  Ariana, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Ben Saad","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Plant Improvement Center of Biotechnology of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Sayahi","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Plant Improvement Center of Biotechnology of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-4743","authenticated-orcid":false,"given":"Wissem","family":"Mnif","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Arts in Balgarn PO BOX 60 Balgarn \u2010 Sabt Al Alaya 61985 University of Bisha  Kingdom of Saudi Arabia"},{"name":"University of Manouba, ISBST, BVBGR\u2010LR11ES31, Biotechnopole Sidi Thabet  Ariana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5626-7084","authenticated-orcid":false,"given":"Walid","family":"Saibi","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Plant Improvement Center of Biotechnology of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-153X-6-140"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.1.38"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.07.018"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34431"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.08.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2014.10.022"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.09.106"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010070"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2013.09.002"},{"key":"e_1_2_7_11_1","first-page":"263","article-title":"Characterization of a S\u2010adenosyl\u2010L\u2010methionine: eriodictyol 4'\u2010O\u2010methyltransferase from Citrus aurantium. 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