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Epigenetics is involved in the development of many diseases, and it is closely associated with fibrosis. In this study, we investigated whether DNA methylation contributes to the pathogenesis of pulmonary fibrosis in pneumoconiosis. By exposure to coal dust or silica dust, we established the models of coal worker's pneumoconiosis (CWP), which showed an increased expression of COL\u2010I, COL\u2010III. We further found that DNMT1, DNMT3a, DNMT3b, MBD2, MeCP2 protein expression changed. Pretreatment with DNMT inhibitor 5\u2010aza\u2010dC reduced expression of COL\u2010I, COL\u2010III, and reduced pulmonary fibrosis. In summary, our results showed that DNA methylation contributes to dust\u2010induced pulmonary fibrosis and that it may serve as a theoretical basis for testing DNA methyltransferase inhibitors in the treatment of CWP.<\/jats:p>","DOI":"10.1002\/tox.22739","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T09:49:25Z","timestamp":1551347365000},"page":"728-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Dust induces lung fibrosis through dysregulated DNA methylation"],"prefix":"10.1002","volume":"34","author":[{"given":"Na","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health School of Public Health and Management, Ningxia Medical University  Yinchuan Ningxia People's Republic of 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