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NRG (50mg\/Kg), was orally given one hour after the first radiation dose, and daily continued during the irradiation period. Rats were sacrificed 1 day after the last dose of radiation. NRG showed a significant decrease of malondialdehyde, hydrogen peroxide with a significant elevation of superoxide dismutase, catalase and glutathione peroxidase activities and glutathione content. Moreover, NRG confirmed the intracellular defense mechanisms through activation of nuclear factor (erythroid\u2010derived 2)\u2010like2 (<jats:italic>Nrf2<\/jats:italic>) and <jats:italic>haem oxygenase\u20101<\/jats:italic> (HO\u20101) levels and their protein expression. In addition, NRG deactivated the nuclear factor\u2010\u03baB (NF\u2010\u03baB) and reduced the pro\u2010inflammatory cytokines. Further, NRG showed positive modulation in the haematological values (WBCs, RBCs, Hb, Hct% and PLt). In conclusion, these results suggested that NRG reversed the IR\u2010induced redox\u2010imbalance in the rat spleen.<\/jats:p>","DOI":"10.1002\/tox.22745","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T13:21:14Z","timestamp":1551964874000},"page":"788-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The effect of naringenin on the role of nuclear factor (erythroid\u2010derived 2)\u2010like2 (Nrf2) and <i>haem oxygenase 1<\/i> (HO\u20101) in reducing the risk of oxidative stress\u2010related radiotoxicity in the spleen of rats"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9726-762X","authenticated-orcid":false,"given":"Nadia","family":"Abdel\u2010Magied","sequence":"first","affiliation":[{"name":"Radiation Biology Research Department National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA)  Cairo 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