{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:28:59Z","timestamp":1778927339824,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI Grant","award":["26670331, 18H03039 and 18K19681"],"award-info":[{"award-number":["26670331, 18H03039 and 18K19681"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The synergic allergic inflammatory effects of particulate matter (PM) 2.5 and human albumin were investigated in NC\/Nga mice, which are hypersensitive to mite allergens. PM2.5 or PM2.5 plus human albumin with aluminum oxide was injected twice intraperitoneally for sensitization. After 7 days, PM2.5 or PM2.5 plus human albumin was administered five times intranasally to mice for further sensitization. Subsequently, PM2.5 was administered as a challenge on the 11th day. On the 12th day, mice were examined for airway hyperresponsiveness (AHR), bronchoalveolar lavage fluid (BALF) cell count, mRNA expression of Th<jats:sub>1<\/jats:sub>, Th<jats:sub>2<\/jats:sub> cytokines, chemokines, and mucus proteins (MUC5AC and MUC5B) in the lung tissue and histopathology. Although PM2.5 or human albumin alone did not induce allergic airway inflammation, simultaneous inoculation of PM2.5 and human albumin\u2010induced airway inflammation showing increase in AHR, total BALF cell numbers, mRNA levels of IL\u201013, eotaxin 1, eotaxin 2, and MUC5AC, and anti\u2010IG against human serum albumin. Inflammation was observed around the bronchus in PM2.5 plus human albumin\u2010induced lungs. These results demonstrate that PM2.5 can induce allergic airway inflammation through the synergistic action with human albumin in NC\/Nga mice.<\/jats:p>","DOI":"10.1002\/tox.22751","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T10:58:26Z","timestamp":1554548306000},"page":"836-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Human albumin augmented airway inflammation induced by PM2.5 in NC\/Nga mice"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7861-3910","authenticated-orcid":false,"given":"Kenjiro","family":"Nagaoka","sequence":"first","affiliation":[{"name":"Department of Public Health Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiki","family":"Ogino","sequence":"additional","affiliation":[{"name":"Department of Public Health Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyoshi","family":"Ogino","sequence":"additional","affiliation":[{"name":"Department of Public Health Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science  Okayama Japan"},{"name":"Third Department of Internal Medicine School of Medicine, University of Occupational and Environmental Health Japan  Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Public Health Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Public Health Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihona","family":"Ogino","sequence":"additional","affiliation":[{"name":"Department of Public Health Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science  Okayama Japan"},{"name":"First Department of Internal Medicine School of Medicine, University of Occupational and Environmental Health Japan  Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Public Health Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Life Science Okayama University of Science  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Fujikura","sequence":"additional","affiliation":[{"name":"Division of Morphological Analysis, Department of Anatomy, Biology and Medicine, Faculty of Medicine Oita University  Yufu Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312093292401"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1994.1005"},{"issue":"3","key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1164\/ajrccm.151.3.7881654","article-title":"Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults","volume":"151","author":"Pope CA","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60898-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201403-0525OC"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-010-0150-5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00202.2003"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11229"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/08958371003631608"},{"issue":"8","key":"e_1_2_5_11_1","first-page":"785","article-title":"Ambient PM2.5 exposure exacerbates severity of allergic asthma in previously sensitized mice","volume":"52","author":"Zhang X","year":"2015","journal-title":"J Asthma"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11020291"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.8.2007121"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21791"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092710"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22303"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/B303132B"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000095296"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00418.2006"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.06.020"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl767"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1013"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/1071576021000016427"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.4844"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901461"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02586.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099472"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/35037026"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.70.113006.100702"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32831da8d3"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7281"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2005"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1415OC"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42675"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.2.1001"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/614345"},{"issue":"12","key":"e_1_2_5_37_1","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.4049\/jimmunol.136.12.4525","article-title":"Bacterial lipopolysaccharide\u2010induced interferon\u2010gamma production: roles of interleukin 1 and interleukin 2","volume":"136","author":"Le J","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.79.5.623"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6300"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/096032706072520"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftox.22751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tox.22751","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:01:20Z","timestamp":1694354480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.22751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,5]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/tox.22751"],"URL":"https:\/\/doi.org\/10.1002\/tox.22751","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,5]]},"assertion":[{"value":"2018-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}