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The present study aimed to explore the role of autophagy in the neurotoxic effect induced by excessive iodine <jats:italic>in vivo<\/jats:italic>. The Morris water maze test results demonstrated that excessive iodine impaired the learning and memory capabilities of rats, which were associated with marked body weight and brain weight abnormalities. In addition, iodine treatment increased malondialdehyde accumulation, decreased superoxide dismutase activity and glutathione (GSH) level, and enhanced levels of autophagy markers in the hippocampus. Notably, inhibition of autophagy with 3\u2010methyladenine (3\u2010MA) could significantly alleviate excessive iodine\u2010induced cognitive impairment. These data imply that autophagy is involved in the cognitive impairment elicited by excessive iodine as a pathway of cell death, and inhibition of autophagy via 3\u2010MA may significantly alleviate the above damage.<\/jats:p>","DOI":"10.1002\/tox.22762","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T05:39:30Z","timestamp":1557466770000},"page":"912-920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["3\u2010Methyladenine alleviates excessive iodine\u2010induced cognitive impairment via suppression of autophagy in rat hippocampus"],"prefix":"10.1002","volume":"34","author":[{"given":"Liang","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Environment and Health, Tianjin Centers for Disease Control and Prevention  Tianjin 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