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The viability of Cd treated cells was reduced to 19.9%\u2009\u00b1\u20092.4% in comparison to the untreated cells, whereas the viability of DADS pretreated cells was increased to 48.6%\u2009\u00b1\u20092%. The attenuation effect of DADS was studied at shorter period (6 hours). Transcriptome analysis of CdCl<jats:sub>2<\/jats:sub> alone treated cells resulted in 2119 and 982 (up and down) regulated genes (\u2265\u20092 or \u2264\u20092\u2010fold), whereas pretreated cells with DADS resulted in 2597 and 1784 genes. These genes were known to function in many important biological processes. Affymetrix array analysis was validated by the pathway specific PCR array that exhibited the same trend of expression. The current study clearly shows the DADS attenuation effect on transcriptome in CdCl<jats:sub>2<\/jats:sub>\u2010treated rat liver cells.<\/jats:p>","DOI":"10.1002\/tox.22766","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T14:04:22Z","timestamp":1557583462000},"page":"950-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diallyl disulfide attenuation effect on transcriptome in rat liver cells against cadmium chloride toxicity"],"prefix":"10.1002","volume":"34","author":[{"given":"Ahkinyala","family":"Cobb\u2010Abdullah","sequence":"first","affiliation":[{"name":"School of the Environment Florida A&amp;M University  Tallahassee Florida"},{"name":"School of Arts and Sciences Virginia Union University  Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Leonard 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