{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T18:41:15Z","timestamp":1784572875521,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402703"],"award-info":[{"award-number":["81402703"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11504375"],"award-info":[{"award-number":["11504375"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51571186"],"award-info":[{"award-number":["51571186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2014CB931704"],"award-info":[{"award-number":["2014CB931704"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate the protective effects of Nano\u2010Se against Ni\u2010induced testosterone synthesis disorder in rats and determine the underlying protective mechanism. Sprague\u2010Dawley rats were co\u2010treated with Ni (5.0 mg\/kg, i.p.) and Nano\u2010Se (0.5, 1.0, and 2.0 mg\/kg, oral gavage) for 14 days after which various endpoints were evaluated. The Ni\u2010induced abnormal pathological changes and elevated 8\u2010OHdG levels in the testes were attenuated by Nano\u2010Se administration. Importantly, decreased serum testosterone levels in the Ni\u2010treated rats were significantly restored by Nano\u2010Se treatment, particularly at 1.0 and 2.0 mg\/kg. Furthermore, the mRNA and protein levels of testosterone synthetase were increased by Nano\u2010Se compared to the Ni group, whereas phosphorylated protein expression levels of mitogen\u2010activated protein kinase (MAPK) pathways were suppressed by Nano\u2010Se administration in the Ni\u2010treated rats. Overall, the results suggest that Nano\u2010Se may ameliorate the Ni\u2010induced testosterone synthesis disturbance via the inhibition of ERK1\/2, p38, and JNK MAPK pathways.<\/jats:p>","DOI":"10.1002\/tox.22768","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T14:08:05Z","timestamp":1557583685000},"page":"968-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nano\u2010selenium attenuates nickel\u2010induced testosterone synthesis disturbance through inhibition of MAPK pathways in Sprague\u2010Dawley rats"],"prefix":"10.1002","volume":"34","author":[{"given":"Xiaoqin","family":"Gan","sequence":"first","affiliation":[{"name":"Department of Toxicology, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiannan","family":"E","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixing","family":"Ye","sequence":"additional","affiliation":[{"name":"Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijie","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-4770","authenticated-orcid":false,"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Hefei Institutes of Physical Science Chinese Academy of Sciences  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/395741"},{"issue":"4","key":"e_1_2_7_3_1","first-page":"685","article-title":"The impact of nickel on human health","volume":"13","author":"Aleksandra DC","year":"2008","journal-title":"J Elem"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000213Y.0000000055"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1730"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-013-9617-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5487\/TR.2011.27.2.061"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00234-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf304562b"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00906.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.07.016"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.08.003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101939200"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16129983"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10934529.2012.672114"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2018.03.016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.12.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20756"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/821615"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430150"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2016.04.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.1.181"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2002153"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1060291"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/152308603764816569"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520150103"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm221"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-9891-0"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328214523323"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2415-1"},{"issue":"2013","key":"e_1_2_7_31_1","first-page":"1713","article-title":"The prospective protective effect of selenium nanoparticles against chromium\u2010induced oxidative and cellular damage in rat thyroid","volume":"8","author":"Hassanin KM","year":"2013","journal-title":"Int J Nanomedicine"},{"issue":"6","key":"e_1_2_7_32_1","first-page":"578","article-title":"Selenium supplementation in the form of selenium nanoparticles and selenite sodium improves mature male mice reproductive performances","volume":"21","author":"Asri\u2010Rezaei S","year":"2018","journal-title":"Iran J Basic Med Sci"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.11.025"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2011.556156"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-0980-8"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.897689"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2004.tb03173.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.07.021"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.04.013"},{"issue":"147","key":"e_1_2_7_40_1","first-page":"1","article-title":"Selenocystine against methyl mercury cytotoxicity in HepG2 cells","volume":"7","author":"Wang H","year":"2017","journal-title":"Sci Rep"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2016.03.001"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-148-38697"},{"issue":"2013","key":"e_1_2_7_43_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brainres.2013.07.028","article-title":"Effects of low\u2010level organic selenium on lead\u2010induced alterations in neural cell adhesion molecules","volume":"1530","author":"Wang M","year":"2013","journal-title":"Brain Res"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2014.05.009"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.07.003"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.01.024"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540240035027"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-016-0748-6"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2015.09.004"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2014.956912"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139311"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-17-0064"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2007.112"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-013-0035-8"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.12.027"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-010-0362-1"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.5099\/aj090300226"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tox.22768","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T14:57:25Z","timestamp":1694271445000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.22768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,11]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/tox.22768"],"URL":"https:\/\/doi.org\/10.1002\/tox.22768","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,11]]},"assertion":[{"value":"2018-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}