{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:29:50Z","timestamp":1770956990676,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Coridius chinensis<\/jats:italic> (<jats:italic>C. chinensis<\/jats:italic>) is a traditional Chinese medicine that has been used to treat pain, erectile dysfunction, and other diseases. Our previous study demonstrated that manganese\u2010induced reproductive damage was partially rescued by a medium dose of <jats:italic>C. chinensis<\/jats:italic> treatment in rat. However, the underlying mechanism is unknown. In this study, we found that the weight of reproductive organs and the sperm count in manganese\u2010exposed rat were partially rescued by <jats:italic>C. chinensis<\/jats:italic> extracts (CcE) treatment. The number of apoptotic cells was significantly decreased and the expression of malondialdehyde, cytochrome <jats:italic>c<\/jats:italic>, and caspase\u20103 in manganese\u2010exposed rats was significantly decreased after high dose of CcE treatment. Further studies revealed that the activity of superoxide dismutase, total antioxidant capacity, and glutathione peroxidase enzymes was significantly increased in testis tissues and serum of manganese\u2010exposed rats with high dose of CcE treatment. Taken together, the results of this study suggest that CcE inhibits the Mn<jats:sup>2+<\/jats:sup>\u2010induced apoptosis in testes by inducing the activity of antioxidants.<\/jats:p>","DOI":"10.1002\/tox.22777","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T14:09:06Z","timestamp":1559138946000},"page":"1067-1073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Antioxidant activity of <i>Coridius chinensis<\/i> extracts on manganese\u2010induced testicular damage in rats"],"prefix":"10.1002","volume":"34","author":[{"given":"Qiongyou","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences Zunyi Medical University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhuo","family":"Cen","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences Zunyi Medical University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences Zunyi Medical University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences Zunyi Medical University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences Zunyi Medical University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences Zunyi Medical University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7713-2808","authenticated-orcid":false,"given":"Xiaohui","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences Zunyi Medical University  Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2005.07.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2008.03.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.10.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000253939.06166.7e"},{"key":"e_1_2_7_6_1","first-page":"216","article-title":"Effects of manganese chloride on the morphology of testis","volume":"29","author":"Cai XL","year":"2006","journal-title":"Acta Acad Med Zunyi"},{"key":"e_1_2_7_7_1","first-page":"551","article-title":"The effect of mangamese on morphology of sperm in rats and its significance","volume":"32","author":"Cai XL","year":"2009","journal-title":"Acta Acad Med Zunyi."},{"key":"e_1_2_7_8_1","first-page":"101","article-title":"Changes of the activity of lactate dehydrogenase (LDH) in serum and testis of rats exposed to manganese","volume":"33","author":"Cai XL","year":"2010","journal-title":"Acta Acad Med Zunyi"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.07.058"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-012-9549-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.07.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol403409v"},{"key":"e_1_2_7_13_1","first-page":"258","article-title":"Protection of stink\u2010bug on manganese\u2010induced reproductive damage to male rats","volume":"38","author":"He ZQ","year":"2016","journal-title":"Chin Tradit Pat Med"},{"key":"e_1_2_7_14_1","first-page":"400","article-title":"Effect of manganese on caspase\u20103 mRNA regulation in spermatogenic cell and the expression of vimentin on sertoli cell in rats","volume":"41","author":"Cai XL","year":"2010","journal-title":"Acta Anat Sin"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422371112"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.22.9899-9910.2004"},{"key":"e_1_2_7_17_1","first-page":"187","article-title":"Study on the relationship of antioxidant activity with structure on flavonoids as scavengers of superoxide anion","volume":"33","author":"Zhang L","year":"2006","journal-title":"J Zhejiang Univ"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2012.12.024"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2016.12.015"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-919"},{"key":"e_1_2_7_21_1","first-page":"4030","article-title":"Effects of manganese on SOD\/(CAT+GSH\u2010Px) and the expression of p53 and Bcl\u20102 in rat testis","volume":"35","author":"Cai XL","year":"2008","journal-title":"Mod Prev Med"},{"key":"e_1_2_7_22_1","first-page":"85","article-title":"Effect of manganese on apoptosis of spermatogenic cell of rats","volume":"34","author":"Zhang XP","year":"2008","journal-title":"Ind Health Occup Dis"},{"key":"e_1_2_7_23_1","first-page":"500","article-title":"The role of mitochondria mediated apoptosis pathway in sertoli\u2010germ cell apoptosis induced by manganese in cocks","volume":"41","author":"Bi MY","year":"2010","journal-title":"Chin J Anim Vet Sci"},{"key":"e_1_2_7_24_1","first-page":"65","volume-title":"Food Nutrition","author":"Sun YM","year":"2002"},{"key":"e_1_2_7_25_1","first-page":"748","article-title":"Analysis of nutritional components of Aspongopus chinensis in Guizhou","volume":"47","author":"Li L","year":"2010","journal-title":"Chin Bull Entomol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-8690-5"},{"key":"e_1_2_7_27_1","first-page":"545","article-title":"Analysis on volatile components of Aspongopus chinensis by HS\u2010SPME and GC\u2010MS","volume":"56","author":"Fu HH","year":"2017","journal-title":"Hubei Agric Sci"},{"key":"e_1_2_7_28_1","first-page":"924","article-title":"Discussion on the repair mechanism of the rat reproductive injury caused by Aspongopus chinensis","volume":"38","author":"He ZQ","year":"2016","journal-title":"Chin Tradit Pat Med"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tox.22777","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T05:27:59Z","timestamp":1694323679000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.22777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,29]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/tox.22777"],"URL":"https:\/\/doi.org\/10.1002\/tox.22777","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,29]]},"assertion":[{"value":"2018-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}