{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:30:45Z","timestamp":1762299045633,"version":"3.40.5"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Code 001"],"award-info":[{"award-number":["Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to evaluate the effects of maternal exposure to triclosan (TCS) during pregnancy and lactation on the uterine morphology of rat offspring. For this, 32 Wistar rat dams were distributed into four dose groups (eight mothers per group), and gavage daily, throughout pregnancy and lactation, as follows: Group I\u2013control (GI): corn oil; Group II (GII): TCS diluted in corn oil at a dose of 75\u2009mg\/kg\/d; Group III (GIII): TCS diluted in corn oil at a dose of 150\u2009mg\/kg\/d; Group IV (GIV): TCS diluted in corn oil at a dose of 300\u2009mg\/kg\/d. A female pup of each mother was selected, and at 90\u2009days the pups were euthanized for weighing and collection of the uterus for histomorphometric analysis. The results showed that the mean litter weight was minor in all the groups treated with TCS, when compared with control. The levels thyroid hormones thyroxine (T4) and triiodothyronine (T3) in TCS mother rats were reduced; however the levels of thyroid stimulating hormone (TSH) were increases. The offspring of all groups exposed to TCS presented deregulation of the estrous cycle, compared with control. Analysis of the uterine histological structure demonstrated that all layers of the uterus were affected by the administration of TCS, and the morphometric analysis showed increased uterine layers thickness in the treated groups. We concluded that maternal exposure to TCS during pregnancy and lactation causes intrauterine development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring.<\/jats:p>","DOI":"10.1002\/tox.22812","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T06:15:46Z","timestamp":1561529746000},"page":"1105-1113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Maternal exposure to triclosan causes fetal development restriction, deregulation of the oestrous cycle, and alters uterine tissue in rat offspring"],"prefix":"10.1002","volume":"34","author":[{"given":"Guilherme","family":"Bitencourt","sequence":"first","affiliation":[{"name":"State University of Western Parana (UNIOESTE)  Cascavel Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo D.","family":"Fortunato","sequence":"additional","affiliation":[{"name":"State University of Western Parana (UNIOESTE)  Cascavel Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Panis","sequence":"additional","affiliation":[{"name":"State University of Western Parana (UNIOESTE)  Cascavel Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2245-548X","authenticated-orcid":false,"given":"Elaine M. P.","family":"Amorim","sequence":"additional","affiliation":[{"name":"State University of Western Parana (UNIOESTE)  Cascavel Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o P.","family":"de Arruda Amorim","sequence":"additional","affiliation":[{"name":"State University of Western Parana (UNIOESTE)  Cascavel Paran\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1080\/10590501.2010.504978"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1093\/toxsci\/kfq180"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1002\/jat.1660"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1289\/EHP1788"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"133","article-title":"Effects of triclosan on various aquatic organisms","volume":"11","author":"Tatarazako N","year":"2004","journal-title":"Environ Sci"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1016\/S0045-6535(01)00255-7"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1016\/j.scitotenv.2006.08.007"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1289\/ehp.10768"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1016\/j.scitotenv.2012.12.052"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1016\/j.envres.2014.12.007"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1016\/j.ijheh.2015.04.003"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1016\/j.envint.2016.03.019"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1016\/j.fct.2006.08.009"},{"key":"e_1_2_8_15_1","article-title":"Detection of phenolic endocrine disrupting chemicals from maternal blood plasma and amniotic fluid in Indian population","volume":"241","author":"Shekhar S","year":"2016","journal-title":"Gen Comp Endocrinol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1016\/j.envint.2014.12.003"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1111\/jcpe.12519"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1034\/j.1600-051X.2003.20030.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.14219\/jada.archive.2006.0110"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1016\/j.reprotox.2012.05.094"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1016\/S0141-1136(00)00080-5"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_1","DOI":"10.1016\/j.aquatox.2003.12.005"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1016\/j.aquatox.2006.08.010"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1016\/j.etap.2007.04.008"},{"doi-asserted-by":"publisher","key":"e_1_2_8_25_1","DOI":"10.1016\/j.reprotox.2008.12.002"},{"doi-asserted-by":"publisher","key":"e_1_2_8_26_1","DOI":"10.1093\/toxsci\/kfp271"},{"doi-asserted-by":"publisher","key":"e_1_2_8_27_1","DOI":"10.1016\/j.toxlet.2011.10.017"},{"doi-asserted-by":"publisher","key":"e_1_2_8_28_1","DOI":"10.1016\/j.tox.2012.05.023"},{"doi-asserted-by":"publisher","key":"e_1_2_8_29_1","DOI":"10.1016\/j.reprotox.2012.12.001"},{"doi-asserted-by":"publisher","key":"e_1_2_8_30_1","DOI":"10.1038\/srep18252"},{"doi-asserted-by":"publisher","key":"e_1_2_8_31_1","DOI":"10.1210\/er.2009-0002"},{"doi-asserted-by":"publisher","key":"e_1_2_8_32_1","DOI":"10.1016\/j.fct.2013.06.050"},{"doi-asserted-by":"publisher","key":"e_1_2_8_33_1","DOI":"10.1002\/etc.339"},{"doi-asserted-by":"publisher","key":"e_1_2_8_34_1","DOI":"10.3390\/ijerph13020224"},{"doi-asserted-by":"publisher","key":"e_1_2_8_35_1","DOI":"10.1016\/S0196-6553(96)90017-6"},{"doi-asserted-by":"publisher","key":"e_1_2_8_36_1","DOI":"10.1016\/0006-8993(71)90526-9"},{"doi-asserted-by":"publisher","key":"e_1_2_8_37_1","DOI":"10.1017\/S0007114599000173"},{"doi-asserted-by":"publisher","key":"e_1_2_8_38_1","DOI":"10.1590\/S1519-69842002000400008"},{"doi-asserted-by":"publisher","key":"e_1_2_8_39_1","DOI":"10.1002\/bdrb.20106"},{"key":"e_1_2_8_40_1","first-page":"469","article-title":"Morphometric analysis of the endometrial epithelium of rats (Rattus norvegicus albinus) submitted to chronic experimental alcoholism","volume":"31","author":"Martinez M","year":"1999","journal-title":"J Submicrosc Cytol Pathol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_41_1","DOI":"10.1590\/S0100-72032009000900006"},{"doi-asserted-by":"publisher","key":"e_1_2_8_42_1","DOI":"10.1210\/me.2016-1086"},{"doi-asserted-by":"publisher","key":"e_1_2_8_43_1","DOI":"10.1210\/jc.2012-2540"},{"doi-asserted-by":"publisher","key":"e_1_2_8_44_1","DOI":"10.1038\/srep44803"},{"doi-asserted-by":"publisher","key":"e_1_2_8_45_1","DOI":"10.1016\/j.tiv.2016.01.014"},{"doi-asserted-by":"publisher","key":"e_1_2_8_46_1","DOI":"10.1002\/dvdy.20981"},{"doi-asserted-by":"publisher","key":"e_1_2_8_47_1","DOI":"10.1210\/jc.2010-0354"},{"doi-asserted-by":"publisher","key":"e_1_2_8_48_1","DOI":"10.1016\/j.placenta.2005.02.004"},{"doi-asserted-by":"publisher","key":"e_1_2_8_49_1","DOI":"10.1074\/jbc.M512671200"},{"doi-asserted-by":"publisher","key":"e_1_2_8_50_1","DOI":"10.1016\/j.ejphar.2003.12.035"},{"doi-asserted-by":"publisher","key":"e_1_2_8_51_1","DOI":"10.5603\/FHC.2012.0045"},{"key":"e_1_2_8_52_1","first-page":"297","volume-title":"Textbook of Reproductive Medicine","author":"Stradtman EW","year":"1993"},{"doi-asserted-by":"publisher","key":"e_1_2_8_53_1","DOI":"10.1016\/j.reprotox.2016.09.004"},{"doi-asserted-by":"publisher","key":"e_1_2_8_54_1","DOI":"10.1002\/jat.1736"},{"doi-asserted-by":"publisher","key":"e_1_2_8_55_1","DOI":"10.1016\/j.chemosphere.2012.01.002"},{"doi-asserted-by":"publisher","key":"e_1_2_8_56_1","DOI":"10.1095\/biolreprod63.6.1747"},{"doi-asserted-by":"publisher","key":"e_1_2_8_57_1","DOI":"10.1186\/1477-7827-8-14"},{"doi-asserted-by":"publisher","key":"e_1_2_8_58_1","DOI":"10.1262\/jrd.2014-129"},{"doi-asserted-by":"publisher","key":"e_1_2_8_59_1","DOI":"10.1016\/S0890-6238(01)00130-7"},{"doi-asserted-by":"publisher","key":"e_1_2_8_60_1","DOI":"10.1210\/jc.2004-0507"},{"doi-asserted-by":"publisher","key":"e_1_2_8_61_1","DOI":"10.1530\/REP-07-0167"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftox.22812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tox.22812","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T05:26:11Z","timestamp":1694323571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.22812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,25]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/tox.22812"],"URL":"https:\/\/doi.org\/10.1002\/tox.22812","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"type":"print","value":"1520-4081"},{"type":"electronic","value":"1522-7278"}],"subject":[],"published":{"date-parts":[[2019,6,25]]},"assertion":[{"value":"2019-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}