{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:08:29Z","timestamp":1790017709630,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T00:00:00Z","timestamp":1561248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774364"],"award-info":[{"award-number":["81774364"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was designed to investigate the effects of rhynchophyllin (RH) on neuroinflammation in Tourette syndrome (TS) rats. TS model was established in rats by the injection of selective 5\u2010HT2A\/2C agonist 1\u2010(2, 5\u2010dimethoxy\u20104\u2010iodophenyl)\u20102\u2010aminopropane (DOI). Behavior in DOI\u2010induced rats was tested. Inflammatory cytokines levels such as interleukin\u20101\u03b2 (IL\u20101\u03b2), interleukin\u20106 (IL\u20106), and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) in serum and striatum were detected. The expression levels of janus kinase 2 (JAK2)\/signal transducer and transcription activator 3 (STAT3) and nuclear factor (NF)\u2010\u03baB pathways in striatum were measured by Western blot. Data indicated that RH can significantly reduce the numbers of nodding experiment of TS rats. RH significantly decreased IL\u20106, IL\u20101\u03b2, and TNF\u2010\u03b1 in serum and striatum of TS rats, with altered expression of P\u2010JAK2, P\u2010STAT3, P\u2010NF\u2010\u03baBp65, and P\u2010I\u03baB\u03b1 in TS rats, as evidenced by Western blot analysis and immunohistochemistry, suggesting that the regulation of JAK2\/STAT3 and NF\u2010\u03baB pathways might be involved in the mechanism of RH on TS.<\/jats:p>","DOI":"10.1002\/tox.22813","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T05:08:18Z","timestamp":1561352898000},"page":"1114-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Rhynchophyllin attenuates neuroinflammation in Tourette syndrome rats via JAK2\/STAT3 and NF\u2010\u03baB pathways"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1773-046X","authenticated-orcid":false,"given":"Long","family":"Hongyan","sequence":"first","affiliation":[{"name":"Central Laboratory, Nanjing Hospital of Chinese Medicine The Third Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Mengjiao","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Chunyan","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Yaruo","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2016.01.220"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00117"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-015-0742-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu311"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.5.588"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00132"},{"issue":"5","key":"e_1_2_8_8_1","first-page":"469","article-title":"Effects of fluoxetine and haloperidol on DOI\u2010induced head twitch in mice","author":"Yao Y","year":"2007","journal-title":"Chin J Contemp Pediatr"},{"key":"e_1_2_8_9_1","unstructured":"ZhangF SunAS YuLM WuQ GongQH Effects of isorhynchophylline on angiotensin II\u2010induced proliferation in rat vascular smooth muscle cells. 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