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In this study, Kathon induced apoptotic cell death along with membrane damage at 24 h post\u2010exposure. Additionally, on day 14 after a single instillation with Kathon, the total number of pulmonary cells and the levels of TNF\u2010\u03b1, IL\u20105, IL\u201013, MIP\u20101\u03b1, and MCP\u20101\u03b1 clearly increased in the lung of mice. The proportion of natural killer cells and eosinophils were significantly elevated in the spleen and the bloodstream, respectively, and the level of immunoglobulin (Ig) A, but not IgG, IgM, and IgE, dose\u2010dependently increased. Therefore, we suggest that inhaled Kathon may induce eosinophilia\u2010mediated disease in the lung by disrupting homeostasis of pulmonary surfactants. Considering that eosinophilia is closely related to cancer and fibrosis, further studies are needed to understand the relationship between them.<\/jats:p>","DOI":"10.1002\/tox.22839","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T13:09:15Z","timestamp":1568034555000},"page":"27-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Inhaled Kathon may induce eosinophilia\u2010mediated disease in the lung"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-5351","authenticated-orcid":false,"given":"Eun\u2010Jung","family":"Park","sequence":"first","affiliation":[{"name":"Graduate School of East\u2010West Medical Science Kyung Hee University  Yongin\u2010si, Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Seok","family":"Han","sequence":"additional","affiliation":[{"name":"Toxicologic Pathology Center Korea Institute of Toxicology  Daejeon\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunsol","family":"Seong","sequence":"additional","affiliation":[{"name":"Graduate School of East\u2010West Medical Science Kyung Hee University  Yongin\u2010si, Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Graduate School of East\u2010West Medical Science Kyung Hee University  Yongin\u2010si, Gyeonggi\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung\u2010Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Toxicologic Pathology Center Korea Institute of Toxicology  Daejeon\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Respiratory Disease Research Center Korea Institute of Toxicology  Jeongeup, Jellobuk\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuhong","family":"Lee","sequence":"additional","affiliation":[{"name":"Respiratory Disease Research Center Korea Institute of Toxicology  Jeongeup, Jellobuk\u2010do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","unstructured":"https:\/\/www.cas.org\/support\/documentation\/chemical-substances\/faqs. 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