{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:55:10Z","timestamp":1787165710777,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky\u20102018\u2010it32"],"award-info":[{"award-number":["lzujbky\u20102018\u2010it32"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81828011"],"award-info":[{"award-number":["81828011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Phenanthrene (Phe) female rat model was established to explore the effects of Phe on oxidative stress and inflammation. The rats were randomly divided into three groups including control (C), low (L), and high (H) group. Phe was supplied to L and H groups at the dosage of 180\u2009mg\/kg and 900\u2009mg\/kg orally at first day, and with the dose 90\u2009mg\/kg and 450\u2009mg\/kg by intraperitoneal injection at the last 2\u2009days. The C group was enriched with the same volume of corn oil. The blood, lung, and liver tissues were collected. The superoxide dismutase (SOD), malonaldehyde (MDA), and 8\u2010hydroxy\u20102\u2010deoxyguanosine (8\u2010OHdG) were detected to evaluate oxidative stress. The protein and mRNA expressions of interleukin 6 (IL\u20106), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2), and interleukin 10 (IL\u201010) were detected to evaluate inflammation. Further, the forkhead box transcription factor 3 (Foxp3) was analyzed to hint the injury mechanism of inflammation. The results showed SOD and MDA in lung and liver, and serum 8\u2010OHdG elevated significantly in H groups (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Meanwhile, there were significant increases in the protein and mRNA expression of TNF\u2010\u03b1 and IL\u20106 in lung and liver of H groups (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05). In addition, the protein and mRNA expressions of TGF\u2010\u03b2 and Foxp3 were all decreased significantly in both lung and liver of H groups (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Results demonstrated that an obvious change of Phe exposure could induce oxidative stress and inflammation in female rats. This is a first pilot study to explore the association between Phe exposure and oxidative stress and inflammation using a female rat model.\n                  <\/jats:p>","DOI":"10.1002\/tox.22840","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T02:30:01Z","timestamp":1566959401000},"page":"37-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Effects of phenanthrene on oxidative stress and inflammation in lung and liver of female rats"],"prefix":"10.1002","volume":"35","author":[{"given":"Haitao","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Toxicology, School of Public Health Lanzhou University  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Integrated Chinese and Western Medicine Gynecology Gansu Provincial Maternity and 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