{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:04:09Z","timestamp":1790287449486,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study was carried out to explore the possible deleterious impacts of acrylamide (ACR) on catfish (\n                    <jats:italic>Clarias gariepinus<\/jats:italic>\n                    ). The estimation of mortalities, the examination of the clinical picture, the evaluation of blood parameters, oxidative stress, DNA damage, and the histopathological picture were performed in the liver, kidney, and brain samples of the experimentally ACR\u2010exposed catfish. The 96\u2009hours LC\n                    <jats:sub>50<\/jats:sub>\n                    value was estimated to be 133\u2009mg\/L by the hydrostatic method. Fish were reared in water containing four different concentrations of ACR as follows: 20%, 40%, 60%, and 80% of the estimated LC\n                    <jats:sub>50<\/jats:sub>\n                    for 2\u2009weeks. Abnormal behavioral, clinical, and postmortem responses were depicted. The anemic response including significant decreases in red blood cells, hemoglobin, and packed cell volume following the ascending concentrations of ACR were recorded. The malondialdehyde was significantly increased, whereas reduced glutathione level, superoxide dismutase, and total antioxidant capacity were significantly decreased. The DNA fragmentation assay illustrated a clear laddering pattern in all the tested organs. Notably, the brain was the most influenced organ. It is presumed that ACR contamination showed adverse impacts on the catfish.\n                  <\/jats:p>","DOI":"10.1002\/tox.22863","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T10:56:40Z","timestamp":1572605800000},"page":"300-308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Acrylamide\u2010induced hematotoxicity, oxidative stress, and DNA damage in liver, kidney, and brain of catfish (\n                    <i>Clarias gariepinus<\/i>\n                    )"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-8379","authenticated-orcid":false,"given":"Marwa A.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Cairo University  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai 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Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.01.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.217345"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-015-9588-y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-010-0638-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S95296"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2936"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2012.07.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-011-9577-x"},{"issue":"2","key":"e_1_2_10_10_1","first-page":"119","article-title":"Changes in certain haematological parameters in a siluroid catfish Clariasbatratus (Linn) exposed to 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