{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:03:03Z","timestamp":1791990183887,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH\u2010C108\u2010096"],"award-info":[{"award-number":["TSGH\u2010C108\u2010096"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension (HTN) is one of the most prevalent chronic conditions; it can damage blood vessels and rupture blood vessels can trap in small vessels. This blockage can prevent blood flow and oxygen delivery to brain cells and can result in Alzheimer's disease (AD). HTN\u2010 and AD\u2010mediated long\u2010time memory loss and its treatment remain poorly understood. Plant\u2010derived natural compounds are alternative solutions for effectively treating diseases without any side effects. This study revealed that bioactive peptides extracted from potato hydrolysis suppress HTN\u2010mediated long\u2010term memory (LTM) loss and cell apoptosis, thus improving memory formation and neuronal cell survival in the spontaneously hypertensive rat (SHR) rat model. SHR rats were treated with bioactive peptide IF (10\u2009mg\/kg orally) and angiotensin\u2010converting enzyme inhibitors (5 mg\/kg orally). In this study, we evaluated the molecular expression levels of BDNF\u2010, GluR1\u2010, and CREB\u2010mediated markers protein expression in 24\u2010week\u2010old SHR rats. The study result showed that HTN\u2010induced AD regulated long\u2010term memory (LTM) loss and neuronal degeneration in the SHR animals. The bioactive peptide\u2010treated animals showed an elevated level of survival proteins. Bioactive peptide IF activate CREB\u2010mediated downstream proteins to regulate synaptic plasticity and neuronal survival in the SHR rat model.<\/jats:p>","DOI":"10.1002\/tox.22892","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T06:48:50Z","timestamp":1577774930000},"page":"570-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dipeptide IF prevents the effects of hypertension\u2010induced Alzheimer's disease on long\u2010term memory in the cortex of spontaneously hypertensive rats"],"prefix":"10.1002","volume":"35","author":[{"given":"Yung\u2010Ming","family":"Chang","sequence":"first","affiliation":[{"name":"The School of Chinese Medicine for Post\u2010Baccalaureate I\u2010Shou University  Kaohsiung Taiwan"},{"name":"Chinese Medicine Department E\u2010DA Hospital  Kaohsiung Taiwan"},{"name":"Department of Chinese Medicine 1PT Biotechnology Co., Ltd.  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ashok Kumar","sequence":"additional","affiliation":[{"name":"Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da\u2010Tong","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Tri\u2010Service General Hospital National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Jung","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University  Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Mahalakshmi","sequence":"additional","affiliation":[{"name":"Institute of Research and Development Duy Tan University  Da Nang Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Teng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hospitality Management, College of Agriculture Tunghai University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia H.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Nursing MeiHo University  Pingtung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vijaya Padma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Bharathiar University  Coimbatore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Hsiang","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery Shuang Ho Hospital, Taipei Medical University  New Taipei 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