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Furthermore, natural products are generally used to inhibit cell damage induced by heavy metal. Resveratrol possesses wide biological activities, including anti\u2010inflammation and antioxidative stress. This study was conducted to explore the toxicity of nickel on human bronchial epithelial (BEAS\u20102B) cells and evaluate the protective effect of resveratrol. The results showed that nickel could induce cell apoptosis, increase oxidative stress, and promote the expression of pro\u2010inflammatory cytokines, including tumor necrosis factor\u2010\u03b1, interleukin (IL)\u20101\u03b2, IL\u20106, IL\u20108, C\u2010reaction protein. Western blot analysis showed that nickel activated p38 mitogen\u2010activated protein kinase (MAPK), nuclear factor\u2010kappa B, and nucleotide\u2010binding oligomerization domain\u2010like receptor pyrin\u2010domain\u2010containing protein 3 pathways, while resveratrol could reverse these effects. Our results suggested that resveratrol could protect BEAS\u20102B cells from nickel\u2010induced cytotoxicity. Therefore, resveratrol is a potential chemopreventive agent against nickel\u2010induced lung disease.<\/jats:p>","DOI":"10.1002\/tox.22896","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T14:50:34Z","timestamp":1578927034000},"page":"609-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Resveratrol protects human bronchial epithelial cells against nickel\u2010induced toxicity via suppressing p38 MAPK, NF\u2010\u03baB signaling, and NLRP3 inflammasome activation"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5847-7341","authenticated-orcid":false,"given":"Xiangyu","family":"Cao","sequence":"first","affiliation":[{"name":"School of Life Science Liaoning University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Life Science 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