{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:22:35Z","timestamp":1773807755743,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR\u2010108\u2010057"],"award-info":[{"award-number":["DMR\u2010108\u2010057"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Environmental Toxicology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Excessive intake of high fat diet (HFD) and associated obese conditions are critical contributors of cardiac diseases<jats:italic>.<\/jats:italic> In this study, an active metabolite andrographolide from <jats:styled-content style=\"fixed-case\"><jats:italic>Andrographis paniculata<\/jats:italic><\/jats:styled-content> was found to ameliorate HFD\u2010induced cardiac apoptosis. C57\/BL6 mouse were grouped as control (n = 9), obese (n = 8), low dose (25\u2009mg\/kg\/d) andrographolide treatment (n = 9), and high dose (50\u2009mg\/kg\/d) andrographolide treatment (n = 9). The control group was provided with standard laboratory chow and the other groups were fed with HFD. Andrographolide was administered through oral gavage for 1 week. Histopathological analysis showed increase in apoptotic nuclei and considerable cardiac\u2010damages in the obese group signifying cardiac remodeling effects. Further, Western blot results showed increase in pro\u2010apoptotic proteins and decrease in the proteins of IGF\u20101R\u2010survival signaling. However, feeding of andrographolide significantly reduced the cardiac effects of HFD. The results strongly suggest that andrographolide supplementation can be used for prevention and treatment of cardiovascular disease in obese patients.<\/jats:p>","DOI":"10.1002\/tox.22906","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T14:09:12Z","timestamp":1580911752000},"page":"707-713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Andrographolide mitigates cardiac apoptosis to provide cardio\u2010protection in high\u2010fat\u2010diet\u2010induced obese mice"],"prefix":"10.1002","volume":"35","author":[{"given":"Kuan\u2010Ho","family":"Lin","sequence":"first","affiliation":[{"name":"College of Medicine China Medical University  Taichung Taiwan"},{"name":"Department of Emergency Medicine China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibu","family":"Marthandam Asokan","sequence":"additional","affiliation":[{"name":"Cardiovascular and Mitochondria Related Diseases Research Center Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2097-2240","authenticated-orcid":false,"given":"Wei\u2010Wen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You\u2010Liang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Health and Nutrition Biotechnology Asia University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong\u2010Kuei","family":"Lii","sequence":"additional","affiliation":[{"name":"Department of Nutrition China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayapadma","family":"Viswanadha","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Bharathiar University  Coimbatore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Chinese Medical Science China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's Hospital  Qingyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caixian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's Hospital  Qingyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-0411","authenticated-orcid":false,"given":"Chih\u2010Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Cardiovascular and Mitochondria Related Diseases Research Center Buddhist Tzu Chi Medical Foundation  Hualien Taiwan"},{"name":"Department of Health and Nutrition Biotechnology Asia University  Taichung Taiwan"},{"name":"Graduate Institute of Chinese Medical Science China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2525"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.09.014"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005082-200311000-00007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe020065"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"59","article-title":"Obesity and the risk of heart failure","volume":"35","author":"Clark K","year":"2003","journal-title":"J Insur Med"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200104000-00003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-016-0235-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-019-0356-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.246108"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)01740-0"},{"issue":"2","key":"e_1_2_7_12_1","first-page":"25","article-title":"Potential phytoestrogen alternatives exert cardio\u2010protective mechanisms via estrogen receptors","volume":"7","author":"Shibu MA","year":"2017","journal-title":"Biomedicine (Taiwan)"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22510"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.02.032"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22460"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00572"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.07.018"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22270"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.12.020"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22086"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/846740"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.03.004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1573(200008)14:5<333::AID-PTR584>3.0.CO;2-D"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(03)00159-X"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1996.tb01756.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1998.0373"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.54.370"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2003.12.015"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2007.10.034"},{"key":"e_1_2_7_30_1","first-page":"414","article-title":"Protective effect of hydroalcoholic extract of Andrographis paniculata on ischaemia\u2010reperfusion induced myocardial injury in rats","volume":"135","author":"Ojha SK","year":"2012","journal-title":"Indian J Med Res"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2015-010782"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540105.2019.1611745"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.11.040"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.04.013"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.05.046"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep182"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.286"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2014.11.027"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3402\/fnr.v60.31417"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.05.111"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.315"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-010-0502-z"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12054"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056407"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652412802480826"}],"container-title":["Environmental Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftox.22906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/tox.22906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tox.22906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T03:20:47Z","timestamp":1694056847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tox.22906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,5]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/tox.22906"],"URL":"https:\/\/doi.org\/10.1002\/tox.22906","archive":["Portico"],"relation":{},"ISSN":["1520-4081","1522-7278"],"issn-type":[{"value":"1520-4081","type":"print"},{"value":"1522-7278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,5]]},"assertion":[{"value":"2019-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}